Drug interactions with methotrexate sodium oral and naproxen sod-pseudoephedrine oral

methotrexate sodium oral brand names and other generic formulations include:

Methotrexate (Anti-Rheumatic) Oral, Rheumatrex Oral, Trexall Oral

All generic drug interactions for methotrexate sodium oral (lists will include brand and generic names):

naproxen sod-pseudoephedrine oral brand names and other generic formulations include:

Aleve Cold & Sinus Oral, Aleve Sinus & Headache Oral, Aleve-D Sinus & Cold Oral, Aleve-D Sinus & Headache Oral, All Day Cold & Sinus Oral, All Day Pain Relief Sinus & Co Oral, Cold & Sinus Oral, Sudafed 12 Hr Pressure-Pain Oral, Sudafed 12 Hr Sinus-Pain Oral

All generic drug interactions for naproxen sod-pseudoephedrine oral (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

methotrexate sodium oral and naproxen sod-pseudoephedrine oral

methotrexate sodium oral increases levels of naproxen sod-pseudoephedrine oral by reducing drug clearance through the kidneys. Combination may cause methotrexate toxicity.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Serious - Use AlternativePossible serious or life-threatening interaction. Monitor closely. Use alternatives if available.

methotrexate sodium oral and naproxen sod-pseudoephedrine oral

methotrexate sodium oral increases levels of naproxen sod-pseudoephedrine oral by decreasing renal clearance. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. NSAIDs may reduce tubular secretion of methotrexate and enhan

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

naproxen sod-pseudoephedrine oral and methotrexate sodium oral

naproxen sod-pseudoephedrine oral increases levels of methotrexate sodium oral by reducing drug clearance through the kidneys. Combination may cause methotrexate toxicity.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Serious - Use AlternativePossible serious or life-threatening interaction. Monitor closely. Use alternatives if available.

naproxen sod-pseudoephedrine oral and methotrexate sodium oral

naproxen sod-pseudoephedrine oral increases levels of methotrexate sodium oral by decreasing renal clearance. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. NSAIDs may reduce tubular secretion of methotrexate and enhan

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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