Drug interactions with phenytoin oral and perphenazine-amitriptyline oral

phenytoin oral brand names and other generic formulations include:

Dilantin Infatabs Oral, Dilantin-125 Oral, Lorantoin Oral

All generic drug interactions for phenytoin oral (lists will include brand and generic names):

perphenazine-amitriptyline oral brand names and other generic formulations include:

Duo-Vil 2-10 Oral, Duo-Vil 2-25 Oral, Etrafon 2-10 Oral, Etrafon 2-25 Oral, Etrafon A 4-10 Oral, Etrafon Forte 4-25 Oral, Per-Trip Oral, Triavil 2-10 Oral, Triavil 2-25 Oral, Triavil 4-10 Oral, Triavil 4-25 Oral, Triavil 4-50 Oral

All generic drug interactions for perphenazine-amitriptyline oral (lists will include brand and generic names):
Significant - Monitor CloselySignificant interaction possible (monitoring by your doctor required)

phenytoin oral and perphenazine-amitriptyline oral

phenytoin oral will decrease the level or effect of perphenazine-amitriptyline oral by affects how the drug is eliminated from the body (via what is known as the P-glycoprotein [MDR1] transporter). Phenytoin reduces blood levels or effect of amitriptyline. Tricyclic antidepressants like amitriptyline alter phenytoin levels and may increase the risk of seizure.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Significant - Monitor CloselySignificant interaction possible, monitor closely.

phenytoin oral and perphenazine-amitriptyline oral

phenytoin oral will decrease the level or effect of perphenazine-amitriptyline oral by P-glycoprotein (MDR1) efflux transporter. Monitor therapeutic efficacy of amitriptyline; an increased dose may be required. Serum phenytoin levels should be obtained when tricyclic antidepressant agents are added to therapy due to the potential for impaired phenytoin metabolism and decreased seiz

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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