Drug interactions with ponatinib oral and rifampin iv

ponatinib oral brand names and other generic formulations include:

Iclusig Oral

All generic drug interactions for ponatinib oral (lists will include brand and generic names):

rifampin iv brand names and other generic formulations include:

Rifadin IV

All generic drug interactions for rifampin iv (lists will include brand and generic names):
Significant - Monitor CloselyPotential for interaction

ponatinib oral and rifampin iv

ponatinib oral increases levels of rifampin iv by affects how the drug is eliminated from the body (via what is known as the P-glycoprotein [MDR1] transporter).

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Significant - Monitor CloselyPotential for interaction, monitor.

ponatinib oral and rifampin iv

ponatinib oral increases levels of rifampin iv by P-glycoprotein (MDR1) efflux transporter.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.
Significant - Monitor CloselyPotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

rifampin iv and ponatinib oral

rifampin iv decreases levels of ponatinib oral by altering drug metabolism. The effect of ponatinib may be reduced; avoid this combination unless the benefits outweigh the possible risk. Monitor for signs of reduced effectiveness.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Significant - Monitor CloselyPossible serious or life-threatening interaction. Monitor closely. Use alternatives if available.

rifampin iv and ponatinib oral

rifampin iv decreases levels of ponatinib oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid unless the coadministration outweighs the possible risk of ponatinib underexposure; monitor for signs of reduced efficacy

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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