Drug interactions with spironolactone oral and digoxin oral

spironolactone oral brand names and other generic formulations include:

Aldactone Oral, Spirazone Oral

All generic drug interactions for spironolactone oral (lists will include brand and generic names):

digoxin oral brand names and other generic formulations include:

Cardoxin Oral, Digitek Oral, Lanoxicaps Oral, Lanoxin Oral

All generic drug interactions for digoxin oral (lists will include brand and generic names):
Significant - Monitor CloselySignificant interaction possible (monitoring by your doctor required)

spironolactone oral and digoxin oral

spironolactone oral will increase the level or effect of digoxin oral by affects how the drug is eliminated from the body (via what is known as the P-glycoprotein [MDR1] transporter). Spironolactone increases blood levels of digoxin.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Significant - Monitor CloselySignificant interaction possible, monitor closely.

spironolactone oral and digoxin oral

spironolactone oral will increase the level or effect of digoxin oral by P-glycoprotein (MDR1) efflux transporter. Spironolactone has been shown to increase the half-life of digoxin and subsequent toxicity may occur. Monitor carefully during coadministration

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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