Drug interactions with sulfamethoxazole-trimethoprim oral and methotrexate sodium inj

sulfamethoxazole-trimethoprim oral brand names and other generic formulations include:

Bactrim DS Oral, Bactrim Oral, Bethaprim DS Oral, Cheragan with Tmp Oral, Cofatrim Forte Oral, Comoxol Oral, Cotrim Double-Strength Oral, Cotrim Oral, Dynasep DS Oral, Dynasep SS Oral, Kidtrim DS Oral, Pediatrim Oral, Septra DS Oral, Septra Oral, SMZ-TMP DS Oral, Sulfamar Oral, Sulfamethoprim DS Oral, Sulfamethoprim Oral, Sulfamethoprim SS Oral, Sulfaprim DS Oral, Sulfaprim Oral, Sulfatrim DS Oral, Sulfatrim Oral, Sulfoxaprim DS Oral, Sulfoxaprim SS Oral, Sulmeprim Oral, Sultrex Oral, Sultrim-DS Oral, Triazole Oral, Trisulfam Oral, Trisuprim Oral, Uroplus DS Oral, Uroplus SS Oral

All generic drug interactions for sulfamethoxazole-trimethoprim oral (lists will include brand and generic names):

methotrexate sodium inj brand names and other generic formulations include:

Mexate Inj, Mexate-Aq Inj

All generic drug interactions for methotrexate sodium inj (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

sulfamethoxazole-trimethoprim oral and methotrexate sodium inj

sulfamethoxazole-trimethoprim oral , methotrexate sodium inj . Either increases toxicity of the other by added drug effects. Caution, trimethoprim has been shown to rarely increase bone marrow suppression in patients receiving methotrexate.

Patient Drug Interactions Source: RxList
© 2014 RxList, Inc.
Serious - Use AlternativePossible serious or life-threatening interaction. Monitor closely. Use alternatives if available.

sulfamethoxazole-trimethoprim oral and methotrexate sodium inj

sulfamethoxazole-trimethoprim oral , methotrexate sodium inj . Either increases toxicity of the other by pharmacodynamic synergism. Due to an additive antifolate effect, trimethoprim has been shown to rarely increase bone marrow suppression in patients receiving methotrexate

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2014 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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