Dtic-Dome (Dacarbazine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

Dtic-Dome

Cancer »

What is cancer?

Cancer is the uncontrolled growth of abnormal cells anywhere in a body. The abnormal cells are termed cancer cells, malignant cells, or tumor cells. Many cancers and the abnormal cells that compose the cancer tissue are further identified by the name of the tissue that the abnormal cells originated from (for example, breast cancer, lung cancer, colon cancer). Cancer is not confined to humans; animals and other living organisms can get cancer. Below is a schematic that shows normal cell division and how when a cell is damaged or altered without repair to its system, the cell usually dies. Also shown is what can occur when such damaged or unrepaired cells do not die and become cancer cells and proliferate with uncontrolled growth; a mass of cancer cells develop. Frequently, cancer cells can break away from this original mass of cells, travel through the blood and lymph systems, and lodge in other organs where they can again repeat the ...

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Dtic-Dome

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DTIC-Dome®
(dacarbazine) Sterile

WARNING

It is recommended that DTIC-Dome (dacarbazine) be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.

Hemopoietic depression is the most common toxicity with DTlC-Dome (See WARNING).
Hepatic necrosis has been reported (See WARNING).
Studies have demonstrated this agent to have a carcinogenic and teratogenic effect when used in animals.
In treatment of each patient, the physician must weigh carefully the possibility of achieving therapeutic benefit against the risk of toxicity.

DRUG DESCRIPTION

DTlC-Dome Sterile (dacarbazine) is a colorless to an ivory colored solid which is light sensitive. Each vial contains 100 mg of dacarbazine, or 200 mg of dacarbazine (the active ingredient), anhydrous citric acid and mannitol. DTlC-Dome is reconstituted and administered intravenously (pH 3–4). DTlC-Dome is an anticancer agent. Chemically, DTlC-Dome is 5-(3, 3-dimethyl-l-triazeno)-imidazole-4-carboxamide (DTlC) with the following structural formula:

DTIC-Dome®
(dacarbazine) Structural Formula Illustration

What are the possible side effects of dacarbazine (Dtic-Dome)?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection); or
severe nausea, vomiting, diarrhea, or loss of...

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What are the precautions when taking dacarbazine (Dtic-Dome)?

Before using dacarbazine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, blood disorders, decreased bone marrow function, current infections.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received polio vaccine by mouth or flu vaccine inhaled through the nose.

Since this medication can increase your risk of developing serious infections, wash your hands well to prevent the...

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Last reviewed on RxList: 11/5/2008
This monograph has been modified to include the generic and brand name in many instances.