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Dtic-Dome

Last reviewed on RxList: 11/5/2008
Dtic-Dome Side Effects Center

Last reviewed on RxList 5/6/2016

DTIC-Dome (dacarbazine) is a cancer (antineoplastic) medication used to treat skin cancer (malignant melanoma) and Hodgkin's Disease. DTIC-Dome is available in generic form. Common side effects of DTIC-Dome include:

  • nausea
  • vomiting
  • loss of appetite
  • diarrhea
  • skin rash, or
  • flushing (numbness, warmth, redness, or tingly feeling in your face).

Vomiting may last up to 12 hours. Temporary hair loss may occur. Normal hair growth should return after treatment with DTIC-Dome has ended.

The recommended dosage of DTIC-Dome to treat malignant melanoma is 2 to 4.5mg/kg/day for 10 days. Treatment may be repeated at 4 week intervals. To treat Hodgkin's Disease, the recommended dosage is 150mg/square meter body surface/day for 5 days, in combination with other effective drugs. Treatment may be repeated every 4 weeks. DTIC-Dome may interact with "live" vaccines, or other cancer (chemotherapy) medicines. Tell your doctor all medications and supplements you use. During pregnancy, DTIC-Dome should be used only when prescribed. It is unknown if this drug passes into breast milk. Due to the possible risk to the infant, breastfeeding while using this drug is not recommended.

Our DTIC-Dome (dacarbazine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dtic-Dome Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • severe or continued vomiting;
  • fever, chills, body aches, flu symptoms;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • loss of appetite;
  • diarrhea;
  • temporary hair loss;
  • mild skin rash; or
  • numbness, warmth, redness, or tingly feeling in your face.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Dtic-Dome (Dacarbazine)

Dtic-Dome Professional Information

SIDE EFFECTS

Symptoms of anorexia, nausea, and vomiting are the most frequently noted of all toxic reactions. Over 90% of patients are affected with the initial few doses. The vomiting lasts 1-12 hours and is incompletely and unpredictably palliated with phenobarbital and/or prochlorperazine. Rarely, intractable nausea and vomiting have necessitated discontinuance of therapy with DTlC-Dome. Rarely, DTlC-Dome has caused diarrhea. Some helpful suggestions include restricting the patient's oral intake of food for 4-6 hours prior to treatment. The rapid toleration of these symptoms suggests that a central nervous system mechanism may be involved, and usually these symptoms subside after the first 1 or 2 days.

There are a number of minor toxicities that are infrequently noted. Patients have experienced an influenza-like syndrome of fever to 39°C, myalgias and malaise. These symptoms occur usually after large single doses, may last for several days, and they may occur with successive treatments.

Alopecia has been noted as has facial flushing and facial paresthesia. There have been few reports of significant liver or renal function test abnormalities in man. However, these abnormalities have been observed more frequently in animal studies.

Erythematous and urticarial rashes have been observed infrequently after administration of DTIC-Dome (dacarbazine) . Rarely, photosensitivity reactions may occur.

Read the entire FDA prescribing information for Dtic-Dome (Dacarbazine)

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© Dtic-Dome Patient Information is supplied by Cerner Multum, Inc. and Dtic-Dome Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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