"The U.S. Food and Drug Administration today approved Differin Gel 0.1% (adapalene), a once-daily topical gel for the over-the-counter (OTC) treatment of acne. Differin Gel 0.1% is approved for use in people 12 years of age and older.
Duac Topical Gel
(clindamycin phosphate and benzoyl peroxide) Gel, 1.2%/5%
Important: For use on the skin only (topical use). Do not get DUAC Gel in your mouth, eyes, vagina, or on your lips.
Read this Patient Information before you start using DUAC Gel and each time you get a refill. There may be new information. This information does not take the place of talking with your healthcare provider about your medical condition or your treatment.
What is DUAC Gel?
DUAC Gel is a prescription medicine used on the skin (topical) to treat inflamed acne in people 12 years and older.
Who should not use DUAC Gel?
Do not use DUAC Gel if you have:
- had an allergic reaction to clindamycin, lincomycin, benzoyl peroxide, or any of the ingredients in DUAC Gel. See the end of this leaflet for a complete list of ingredients in DUAC Gel.
- Crohn's disease or ulcerative colitis.
- had inflammation of the colon (colitis) with past antibiotic use.
What should I tell my healthcare provider before using DUAC Gel? Before using DUAC Gel, tell your healthcare provider about all of your medical conditions, including if you:
- plan to have surgery with general anesthesia.
- are sensitive to sunlight.
- are pregnant or plan to become pregnant. It is not known if DUAC Gel will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if DUAC Gel passes into your breast milk. One of the medicines in DUAC Gel is clindamycin. Clindamycin when taken by mouth or by injection has been reported to appear in breast milk. You and your healthcare provider should decide if you will use DUAC Gel while breastfeeding.
Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, herbal supplements, and skin products you use. Using other topical acne products may increase the irritation of your skin when used with DUAC Gel.
- Especially tell your healthcare provider if you take a medicine that contains erythromycin. DUAC Gel should not be used with products that contain erythromycin.
How should I use DUAC Gel?
- Use DUAC Gel exactly as your healthcare provider tells you to use it.
- Before you apply DUAC Gel, wash your face gently with a mild soap, rinse with warm water, and pat the skin dry.
- Apply a thin layer of DUAC Gel to your face 1 time a day, in the evening or as directed by your healthcare provider. Wash your hands with soap and water after applying DUAC Gel.
- Do not get DUAC Gel in your mouth, eyes, nose, vagina, or on your lips. Do not get DUAC Gel on cuts or open wounds.
What should I avoid while using DUAC Gel?
- Limit your time in sunlight. Avoid using tanning beds or sun lamps. If you have to be in sunlight, wear a wide-brimmed hat or other protective clothing. Sunscreen may also be used.
- Talk to your healthcare provider if you spend a lot of time in the sun.
- DUAC Gel may bleach hair or colored fabric.
What are the possible side effects with DUAC Gel?
DUAC Gel may cause serious side effects, including:
- Inflammation of the colon (colitis). Stop using DUAC Gel and call your healthcare provider right away if you have severe watery diarrhea, or bloody diarrhea.
- Allergic reactions. Stop using DUAC Gel and call
your healthcare provider or get help right away if you have any of the
- severe itching
- swelling of your face, eyes, lips, tongue, or throat
- trouble breathing
The most common side effects with DUAC Gel are skin reactions and may include redness, peeling, dryness, and burning. These are not all the possible side effects with DUAC Gel.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store DUAC Gel?
- Store DUAC Gel at room temperature up to 25°C (77°F). Do not freeze DUAC Gel.
- The expiration date of DUAC Gel is 60 days from the date when you fill your prescription.
- Safely throw away expired DUAC Gel.
- Keep the tube tightly closed.
Keep DUAC Gel and all medicines out of the reach of children.
General information about DUAC Gel
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use DUAC Gel for a condition for which it was not prescribed. Do not give DUAC Gel to other people, even if they have the same symptoms you have. It may harm them.
If you would like more information, talk with your healthcare provider. You can also ask your pharmacist or healthcare provider for information about DUAC Gel that is written for health professionals.
For more information, call 1-888-784-3335.
What are the ingredients in DUAC Gel?
Active Ingredients: clindamycin phosphate 1.2% and benzoyl peroxide 5%
Inactive ingredients: carbomer homopolymer (type C), dimethicone, disodium lauryl sulfosuccinate, edetate disodium, glycerin, methylparaben, poloxamer 182, purified water, silicon dioxide, and sodium hydroxide.
Last reviewed on RxList: 2/8/2017
This monograph has been modified to include the generic and brand name in many instances.
Additional Duac Topical Gel Information
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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