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During controlled clinical trials, one case of overdose with pioglitazone was reported. A male patient took 120 mg per day for four days, then 180 mg per day for seven days. The patient denied any clinical symptoms during this period.
In the event of overdosage, appropriate supportive treatment should be initiated according to the patient's clinical signs and symptoms.
An overdosage of glimepiride, as with other sulfonylureas, can produce severe hypoglycemia. Mild episodes of hypoglycemia can be treated with oral glucose. Severe hypoglycemic reactions constitute medical emergencies requiring immediate treatment. Severe hypoglycemia with coma, seizure, or neurological impairment can be treated with glucagon or intravenous glucose. Continued observation and additional carbohydrate intake may be necessary because hypoglycemia may recur after apparent clinical recovery [see WARNINGS AND PRECAUTIONS].
- Initiation in patients with established NYHA Class III or IV heart failure [see BOXED WARNING].
- Use in patients with known hypersensitivity to pioglitazone, glimepiride or any other component of DUETACT [see WARNINGS AND PRECAUTIONS].
- Use in patients with known history of an allergic reaction to sulfonamide derivatives.
Reported hypersensitivity reactions with glimepiride include cutaneous eruptions with or without pruritus as well as more serious reactions (e.g., anaphylaxis, angioedema, Stevens-Johnsons Syndrome, dyspnea) [see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS]This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 11/28/2016
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