April 26, 2017
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Duetact Patient Information including How Should I Take

What should I discuss with my health care provider before taking glimepiride and pioglitazone (Duetact)?

You should not use this medication if you are allergic to glimepiride (Amaryl, Avandaryl) or pioglitazone (Actos), or if you have:

  • severe heart failure;
  • active bladder cancer; or
  • if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure you can safely take glimepiride and pioglitazone, tell your doctor if you have any of these other conditions:

  • congestive heart failure or heart disease;
  • a history of heart attack or stroke; or
  • liver or kidney disease.

Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glimepiride and pioglitazone.

Some women using glimepiride and pioglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.

Women may also be more likely than men to have bone fractures in the upper arm, hand, or foot while taking medicine that contains pioglitazone. Talk with your doctor if you are concerned about this possibility.

Do not take glimepiride and pioglitazone for longer than recommended. Taking this medication for longer than 1 year (12 months) may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.

FDA pregnancy category C. It is not known whether glimepiride and pioglitazone will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether this medication passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking glimepiride and pioglitazone.

How should I take glimepiride and pioglitazone (Duetact)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results

Take glimepiride and pioglitazone with your first meal of the day.

Glimepiride and pioglitazone is only part of a complete program of treatment that also includes diet, exercise, and weight control. Use this medication regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change. Your doctor may want you to stop taking the medicine for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.

Ask your doctor how to adjust your glimepiride and pioglitazone dose if needed. Do not change your medication dose or schedule without your doctor's advice.

Store at room temperature, protected from moisture, heat, and light.

Side Effects Centers

Duetact - User Reviews

Duetact User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Duetact sorted by most helpful. Patient Discussions FAQs

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