May 1, 2017
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Duetact Patient Information Including Side Effects

Brand Names: Duetact

Generic Name: glimepiride and pioglitazone (Pronunciation: glye MEP ir ide and PYE oh GLI ta zone)

What is glimepiride and pioglitazone (Duetact)?

Glimepiride and pioglitazone is a combination of two oral diabetes medicines that help control blood sugar levels.

Glimepiride and pioglitazone is for people with type 2 diabetes who do not use daily insulin injections. Glimepiride and pioglitazone is sometimes given with other diabetes medications when greater blood sugar control is needed.

This medication is not for treating type 1 diabetes.

Glimepiride and pioglitazone may also be used for purposes not listed in this medication guide.

What are the possible side effects of glimepiride and pioglitazone (Duetact)?

Stop using glimepiride and pioglitazone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • stomach pain, blood in your urine, painful urination;
  • swelling in your feet, rapid weight gain, feeling short of breath (even with mild exertion);
  • pale skin, easy bruising or bleeding;
  • pain or burning when you urinate; or
  • dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • nausea, vomiting, weakness, loss of appetite, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure.

Less serious side effects may include:

  • sneezing, stuffy nose, cough, sore throat, or other cold symptoms;
  • gradual weight gain;
  • mild nausea, diarrhea;
  • headache, dizziness, blurred vision; or
  • tooth problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Duetact (pioglitazone hydrochloride and glimepiride tablets) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about glimepiride and pioglitazone (Duetact)?

Do not take glimepiride and pioglitazone for longer than recommended. Taking this medication for longer than 1 year (12 months) may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.

Before taking glimepiride and pioglitazone, tell your doctor if you have congestive heart failure or heart disease, a history of bladder cancer, a history of heart attack or stroke, liver disease, or kidney disease.

Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glimepiride and pioglitazone.

Side Effects Centers

Duetact - User Reviews

Duetact User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Duetact sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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