May 25, 2017
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DuoDote Patient Information Including Side Effects

Brand Names: DuoDote

Generic Name: atropine and pralidoxime (Pronunciation: AT roe peen and PRAL i DOX eem)

What is atropine and pralidoxime (DuoDote)?

Atropine blocks the action of chemical called acetylcholine (ah see til KO leen), which may exist in high levels in the body after a poisoning. Atropine also stimulates the heart and reduces the secretions of the nose, mouth, and lungs to improve breathing.

Pralidoxime reverses muscle weakness or paralysis caused by a poison or nerve agent.

The combination of atropine and pralidoxime is used as an antidote to treat poisoning by a pesticide (insect spray) or a chemical that interferes with the central nervous system, such as nerve gas.

This medication is not effective as an antidote for all types of pesticide poisonings. You may need medications or additional treatments.

Atropine and pralidoxime may also be used for purposes not listed in this medication guide.

What are the possible side effects of atropine and pralidoxime (DuoDote)?

Some of the side effects of atropine and pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • pounding heartbeats or fluttering in your chest;
  • painful or difficult urination;
  • trouble swallowing;
  • feeling like you might pass out;
  • confusion;
  • loss of movement in any part of your body;
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop); or
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious side effects may include:

  • dry mouth, dry nose, dry skin;
  • dry eyes, blurred vision;
  • increased sensitivity of your eyes to light;
  • headache;
  • dizziness, drowsiness;
  • muscle weakness;
  • constipation, stomach pain, bloating, nausea, vomiting;
  • loss of interest in sex, impotence; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the DuoDote (atropine and pralidoxime chloride injection) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about atropine and pralidoxime (DuoDote)?

If possible, before you receive atropine and pralidoxime, tell your doctor if you have heart disease, coronary artery disease, a heart rhythm disorder, high blood pressure, narrow-angle glaucoma, kidney disease, enlarged prostate, urination problems, a breathing disorder such as asthma or COPD, if you are allergic to any medication, or if you have recently had a heart attack.

Also tell your doctor if you are pregnant or breast-feeding.

In an emergency situation it may not be possible before you are treated to tell your caregivers about your health conditions or if you are pregnant or breast-feeding. Make sure any doctor caring for you afterward knows that you have received this medication.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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