Duraclon (Clonidine Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Duraclon

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Duraclon®
(clonidine hydrochloride) Injection, Solution

Duraclon®
(clonidine hydrochloride) Injection

The 500 μg/mL strength product should be diluted prior to use in an appropriate solution.

NOTE: Duraclon® (clonidine injection) (epidural clonidine) is not recommended for obstetrical, postpartum, or peri-operative pain management. The risk of hemodynamic instability, especially hypotension and bradycardia, from epidural clonidine may be unacceptable in these patients. However, in a rare obstetrical, post-partum or peri-operative patient, potential benefits may outweigh the possible risks.

DRUG DESCRIPTION

Duraclon (clonidine hydrochloride injection) is a centrally-acting analgesic solution for use in continuous epidural infusion devices.

Clonidine Hydrochloride, USP, is an imidazoline derivative and exists as a mesomeric compound. The chemical names are Benzenamine, 2,6-dichloro-N-2-imidazolidinylidene monohydrochloride and 2-[(2,6-dichlorophenyl) imino]imidazolidine monohydrochloride. The following is the structural formula:

Duraclon (clonidine hydrochloride) Structural Formula Illustration

C₉H₉Cl₂N₃• HCl Mol. Wt. 266.56

Duraclon (clonidine hydrochloride injection) is supplied as a clear, colorless, preservative-free, pyrogen-free, aqueous sterile solution (pH 5 to 7) in single-dose, 10 mL vials.

Each mL of the 100 μg/mL (0.1 mg/mL) concentration contains 100 μg of Clonidine Hydrochloride, USP and 9 mg Sodium Chloride, USP in Water for Injection, USP. Hydrochloric Acid and/or Sodium Hydroxide may have been added for pH adjustment. Each 10 mL vial contains 1 mg (1000 μg) of clonidine hydrochloride.

Each mL of the 500 μg/mL (0.5 mg/mL) concentration contains 500 μg of Clonidine Hydrochloride, USP and 9 mg Sodium Chloride, USP in Water for Injection, USP. Hydrochloric Acid and/or Sodium Hydroxide may have been added for pH adjustment. Each 10 mL vial contains 5 mg (5000 μg) of clonidine hydrochloride.

Last reviewed on RxList: 8/18/2010
This monograph has been modified to include the generic and brand name in many instances.