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Durezol

Last reviewed on RxList: 6/14/2017
Durezol Side Effects Center

Last reviewed on RxList 6/14/2017

Durezol (difuprednate) Ophthalmic Emulsion 0.05% ophthalmic (for the eye) is a topical anti-inflammatory corticosteroid used to treat eye swelling caused by surgery. Common side effects of Durezol Ophthalmic include:

  • temporary blurred vision,
  • headache,
  • burning/stinging/itching of your eyes,
  • dry or watery eyes,
  • feeling like something is in your eye, or
  • increased sensitivity of your eyes to light.

Use of Durezol for prolonged or repeated periods may result in a new fungal infection. Tell your doctor if you have unlikely but serious side effects of Durezol including:

  • new or increased eye pain/swelling/discharge/redness,
  • eye pain or discomfort in bright light, or
  • vision changes.

The dose of Durezol is one drop instilled into the conjunctival sac of the affected eye(s) 4 times daily beginning 24 hours after surgery and continuing throughout the first 2 weeks of the postoperative period, followed by 2 times daily for a week and then a taper based on the response. It is not likely other drugs you take orally or inject will have an effect on Durezol ophthalmic used in the eyes. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Durezol should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Our Durezol (difuprednate ophthalmic emulsion) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Durezol Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • pain behind your eyes, sudden vision changes, severe headache;
  • sudden eye redness, itching, or other irritation;
  • slow healing after your eye surgery;
  • signs of new eye infection, such as swelling, draining, or crusting of your eyes;
  • eye pain, tunnel vision, or seeing halos around lights; or
  • changes in the color or appearance of your iris (the colored part of your eye).

Less serious side effects may include:

  • mild headache;
  • blurred vision;
  • mild burning, stinging, or itching of your eyes;
  • dry or watery eyes;
  • feeling like something is in your eye; or
  • increased sensitivity of your eyes to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Durezol (Difluprednate Opthalmic Emulsion)

Durezol Professional Information

SIDE EFFECTS

Adverse reactions associated with ophthalmic steroids include elevated intraocular pressure, which may be associated with optic nerve damage, visual acuity and field defects; posterior subcapsular cataract formation; secondary ocular infection from pathogens including herpes simplex, and perforation of the globe where there is thinning of the cornea or sclera.

Ocular Surgery

Ocular adverse reactions occurring in 5-15% of subjects in clinical studies with DUREZOL included corneal edema, ciliary and conjunctival hyperemia, eye pain, photophobia, posterior capsule opacification, anterior chamber cells, anterior chamber flare, conjunctival edema, and blepharitis. Other ocular adverse reactions occurring in 1-5% of subjects included reduced visual acuity, punctate keratitis, eye inflammation, and iritis. Ocular adverse reactions occurring in < 1% of subjects included application site discomfort or irritation, corneal pigmentation and striae, episcleritis, eye pruritis, eyelid irritation and crusting, foreign body sensation, increased lacrimation, macular edema, sclera hyperemia, and uveitis. Most of these reactions may have been the consequence of the surgical procedure.

Endogenous Anterior Uveitis

A total of 200 subjects participated in the clinical trials for endogenous anterior uveitis, of which 106 were exposed to DUREZOL. The most common adverse reactions of those exposed to DUREZOL occurring in 5-10% of subjects included blurred vision, eye irritation, eye pain, headache, increased IOP, iritis, limbal and conjunctival hyperemia, punctate keratitis, and uveitis. Adverse reactions occurring in 2-5% of subjects included anterior chamber flare, corneal edema, dry eye, iridocyclitis, photophobia, and reduced visual acuity.

Read the entire FDA prescribing information for Durezol (Difluprednate Opthalmic Emulsion)

Related Resources for Durezol

Read the Durezol User Reviews »

© Durezol Patient Information is supplied by Cerner Multum, Inc. and Durezol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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