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DynaCirc® (isradipine) is indicated in the management of hypertension. It may be used alone or concurrently with thiazide-type diuretics.
DOSAGE AND ADMINISTRATION
The dosage of DynaCirc® (isradipine) should be individualized. The recommended initial dose of DynaCirc® (isradipine) is 2.5 mg b.i.d. alone or in combination with a thiazide diuretic. An antihypertensive response usually occurs within 2-3 hours. Maximal response may require 2–4 weeks. If a satisfactory reduction in blood pressure does not occur after this period, the dose may be adjusted in increments of 5 mg/day at 2-4 week intervals up to a maximum of 20 mg/day. Most patients, however, show no additional response to doses above 10 mg/day, and adverse effects are increased in frequency above 10 mg/day.
The bioavailability of DynaCirc (isradipine) ® (increased AUC) is increased in elderly patients (above 65 years of age), patients with hepatic functional impairment, and patients with mild renal impairment. Ordinarily, the starting dose should still be 2.5 mg b.i.d. in these patients.
DynaCirc® (isradipine) Capsules
White, imprinted twice with the DynaCirc (isradipine) ® logo and "DynaCirc (isradipine) " on one end, and "Reliant" and "2.5" on the other, twice.
Bottles of 100 capsules (NDC 65726-226-25)
Bottles of 60 capsules (NDC 65726-226-15)
Light pink, imprinted twice with the DynaCirc (isradipine) ® logo and "DynaCirc (isradipine) " on one end, and "Reliant" and "5"on the other, twice.
Bottles of 100 capsules (NDC 65726-227-25)
Bottles of 60 capsules (NDC 65726-227-15)
Store and Dispense
Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-89°F) [see USP Controlled Room Temperature] and dispense in a tight, light-resistant container.
Distributed by: Reliant Pharmaceuticals. Liberty Corner, New Jersey 07938.
Last reviewed on RxList: 4/22/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Dynacirc Information
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