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Dynapen Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Dynapen (dicloxacillin sodium) is used to treat many different types of infections caused by bacteria such as bronchitis, pneumonia, or staphylococcal (also called "staph") infections. It is a penicillin antibiotic. The brand name Dynapen is no longer available in the U.S. Generic versions may be available. Common side effects include nausea, vomiting, stomach pain, vaginal itching or discharge, headache, swollen, black, or "hairy" tongue, or thrush (white patches or inside your mouth or throat).
The dosage of dicloxacillin is based on the patient's medical condition and response to therapy. Dicloxacillin may interact with methotrexate or probenecid. Tell your doctor all prescription and over-the-counter medications you use. Tell your doctor if you are pregnant or plan to become pregnant during treatment with dicloxacillin. Dicloxacillin can make birth control pills less effective, which may result in pregnancy. Dicloxacillin passes into breast milk and may harm a nursing baby. Consult your doctor before breast-feeding.
Our Dynapen (dicloxacillin sodium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Dynapen in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- diarrhea that is watery or bloody;
- fever, chills, body aches, flu symptoms;
- easy bruising or bleeding, unusual weakness;
- urinating less than usual or not at all;
- severe skin rash, itching, or peeling;
- agitation, confusion, unusual thoughts or behavior; or
- seizure (black-out or convulsions).
Less serious side effects may include:
- nausea, vomiting, stomach pain;
- vaginal itching or discharge;
- swollen, black, or "hairy" tongue; or
- thrush (white patches or inside your mouth or throat).
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Dynapen (Dicloxacillin) »
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Dynapen FDA Prescribing Information: Side Effects
Body as a Whole
The reported incidence of allergic reactions to penicillin ranges from 0.7% to 10% (see WARNINGS). Sensitization is usually the result of treatment, but some individuals have had immediate reactions to penicillin when first treated in such cases it is thought that the patients may have had prior exposure to the drug via trace amounts present in milk and vaccines.
Two types of allergic reactions to penicillin are noted clinically immediate and delayed.
Immediate reactions usually occur within 20 minutes of administration and range in severity from urticaria and pruritus to angioneurotic edema, iaryngospasm, bronchospasm, hypotension, vascular collapse and death. Such immediate anaphylatic reactions are very rare (see WARNINGS) and usually occur after parenteral therapy, but have occurred in patients receiving oral therapy. Another type of immediate reaction, an accelerated reaction, may occur between 20 minutes and 48 hours after administration and may include urticaria, pruritus and fever. Although Iaryngeal edema, laryngospasm and hypotension occasionally occur, fatality is uncommon.
Delayed allergic reactions to penicillin therapy usually occur after 48 hours and sometimes as late as two to four weeks after initiation of therapy. Manifestations of this type of reaction include serum sickness-like symptoms (ie, fever, malaise, urticarii, myalgia, arthralgia, abdominal pain) and various skin rashes. Nausea. vomiting, diarrhea, stomatitis, black or harry tongue and other symptoms of gastrointestinal irritation may occur, especially during oral penicillin therapy .
Nervous System REACTIONS
Neurotoxic reactions similar to those observed with penicillin G may occur with large intravenous doses of the peniciilinase-resistant penicillins, especially with patients with renal insufficiency.
Renal tubular damage and interstitial nephritis have been associated with the administration of methicin sodium and infrequently, with the administration of nafcillin and oxacillin. Manifestations of this reacti on may include rash, fever, eosinophilia, hematuria, proteinuria and renal insufficiency. Methicillin-induced nephropathy does not appear to be dose-related and is generally reversible upon prompt discontinuation of therapy.
Hepatotoxicity, characterized by fever, nausea and vomiting associated with abnormal liver function tests, mainly elevated SGOT levels, has been associated with the use of oxacillin.
|RECOMENDED DOSAGES FOR DICLOXACILLIN IN MILD TO MODERATE AND SEVERE INFECTIONS|
|Mild to Moderate||Severe||Mild to Moderate||Severe|
|Dicloxacillin||125 mg every 6 hours||250 mg every 6 hours||12.5 mg/kg/dayb in equally divided doses every 6 hours||25 mg/kg/dayb in equally divided doses every 6 hours|
|b Patients weighing less than 40 kg (88 Ibs.)|
Read the entire FDA prescribing information for Dynapen (Dicloxacillin) »
Additional Dynapen Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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