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Econazole Nitrate Cream

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Econazole Nitrate Cream

CLINICAL PHARMACOLOGY

After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes. Inhibitory concentrations were achieved in the epidermis and as deep as the middle region of the dermis. Less than 1% of the applied dose was recovered in the urine and feces.

Microbiology: Econazole nitrate has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section.

Dermatophytes Yeasts
Epidermophyton floccosum Candida albicans
Microsporum audouini Malassezia furfur
Microsporum canis  
Microsporum gypseum
Trichophyton mentagrophytes
Trichophyton rubrum
Trichophyton tonsurans

Econazole nitrate exhibits broad-spectrum antifungal activity against the following organisms in vitro, but the clinical significance of these data is unknown.

Dermatophytes Yeasts
Trichophyton verrucosum Candida guillermondii
  Candida parapsilosis
Candida tropicalis

Last reviewed on RxList: 5/27/2008
This monograph has been modified to include the generic and brand name in many instances.

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