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Edarbyclor

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Edarbyclor

OVERDOSE

Limited data are available related to overdosage in humans.

Azilsartan Medoxomil

Limited data are available related to overdosage in humans. During controlled clinical trials in healthy subjects, once daily doses up to 320 mg of azilsartan medoxomil were administered for 7 days and were well tolerated. In the event of an overdose, supportive therapy should be instituted as dictated by the patient's clinical status. Azilsartan is not dialyzable.

Chlorthalidone

Symptoms of acute overdosage include nausea, weakness, dizziness, and disturbances of electrolyte balance. The oral LD50 of the drug in the mouse and the rat is more than 25,000 mg/kg body weight. The minimum lethal dose (MLD) in humans has not been established. There is no specific antidote, but gastric lavage is recommended, followed by supportive treatment. Where necessary, this may include intravenous dextrose-saline with potassium, administered with caution.

CONTRAINDICATIONS

  • Edarbyclor is contraindicated in patients with anuria [see WARNINGS AND PRECAUTIONS].
  • Do not coadminister aliskiren with Edarbyclor in patients with diabetes [see DRUG INTERACTIONS].

Last reviewed on RxList: 8/4/2014
This monograph has been modified to include the generic and brand name in many instances.

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