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Associated with Estrogens
(See WARNINGS regarding induction of neoplasia, adverse effects on the fetus, increased incidence of gallbladder disease, and adverse effects similar to those of oral contraceptives, including thromboembolism). The following additional adverse reactions have been reported with estrogenic therapy, including oral contraceptives:
Breakthrough bleeding, spotting, change in menstrual
Amenorrhea during and after treatment.
Increase in size of uterine fibromyomata.
Change in cervical erosion and in degree of cervical secretion.
Tenderness, enlargement, secretion.
Abdominal cramps, bloating.
Steepening of corneal curvature.
Intolerance to contact lenses.
Associated with Methyltestosterone
Endocrine And Urogenital
- Female: The most common side effects of androgen therapy are amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement. The latter usually is not reversible after androgens are discontinued. When administered to a pregnant woman androgens cause virilization of external genitalia of the female fetus.
- Skin and Appendages: Hirsutism, male pattern of baldness, and acne.
- Fluid and Electrolyte Disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
- Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function test, rarely hepatocellular neoplasms, and peliosis hepatis (see WARNINGS).
- Hematologic: Suppression of clotting factors, II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
- Nervous System: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
- Metabolic: Increased serum cholesterol.
- Miscellaneous: Inflammation and pain at site of intramuscular injection or subcutaneous implantation of testosterone containing pellets, stomatitis with buccal preparations, and rarely anaphylactoid reactions.
Read the EEMT (esterified estrogens and methyltestosterone tablets) Side Effects Center for a complete guide to possible side effects
- Anticoagulants C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. Patients receiving oral anticoagulant therapy require close monitoring, especially when androgens are started or stopped.
- Oxyphenbutazone. Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
- Insulin. In diabetic patients the metabolic effects of androgens may decrease blood glucose and insulin requirements.
Drug/Laboratory Test Interferences
Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased T serum levels and increased resin uptake of T and T . Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 4/1/2014
Additional EEMT Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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