August 24, 2016
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EEMT Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 4/12/2016

EEMT (esterified estrogens and methyltestosterone) is a combination of the female hormone estrogen and the male hormone testosterone used to treat moderate to severe vasomotor symptoms associated with menopause in those patients not improved by estrogens alone. Common side effects of EEMT include:

The usual dosage range is 1 tablet of EEMT full strength or 1 to 2 tablets of EEMT half strength daily as recommended by the physician. EEMT may interact with anticoagulants, oxyphenbutazone, and insulin. Tell your doctor all medications and supplements you use. EEMT is not recommended for use during pregnancy. It may harm a fetus. It is unknown if this drug passes into breast milk. Because many drugs pass into breast milk, consult your doctor before breastfeeding.

Our EEMT (esterified estrogens and methyltestosterone) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

EEMT FDA Prescribing Information: Side Effects
(Adverse Reactions)


Associated with Estrogens

(See WARNINGS regarding induction of neoplasia, adverse effects on the fetus, increased incidence of gallbladder disease, and adverse effects similar to those of oral contraceptives, including thromboembolism). The following additional adverse reactions have been reported with estrogenic therapy, including oral contraceptives:

Genitourinary system

Breakthrough bleeding, spotting, change in menstrual flow.
Premenstrual-like syndrome.
Amenorrhea during and after treatment.
Increase in size of uterine fibromyomata.
Vaginal candidiasis.
Change in cervical erosion and in degree of cervical secretion.
Cystitis-like syndrome.


Tenderness, enlargement, secretion.


Nausea, vomiting.
Abdominal cramps, bloating.
Cholestatic jaundice.


Chloasma or melasma which may persist when drug is discontinued.
Erythema multiforme.
Erythema nodosum.
Hemorrhagic eruption.
Loss of scalp hair.


Steepening of corneal curvature.
Intolerance to contact lenses.


Headache, migraine, dizziness.
Mental depression.


Increase or decrease in weight.
Reduced carbohydrate tolerance.
Aggravation of porphyria.
Changes in libido.

Associated with Methyltestosterone

Endocrine And Urogenital
  1. Female: The most common side effects of androgen therapy are amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement. The latter usually is not reversible after androgens are discontinued. When administered to a pregnant woman androgens cause virilization of external genitalia of the female fetus.
  2. Skin and Appendages: Hirsutism, male pattern of baldness, and acne.
  3. Fluid and Electrolyte Disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
  4. Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function test, rarely hepatocellular neoplasms, and peliosis hepatis (see WARNINGS).
  5. Hematologic: Suppression of clotting factors, II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
  6. Nervous System: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
  7. Metabolic: Increased serum cholesterol.
  8. Miscellaneous: Inflammation and pain at site of intramuscular injection or subcutaneous implantation of testosterone containing pellets, stomatitis with buccal preparations, and rarely anaphylactoid reactions.

Read the entire FDA prescribing information for EEMT (Esterified Estrogens and Methyltestosterone Tablets)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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