Eldepryl (Selegiline Hcl) Drug Information: Medication Guide and Patient Information

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May 27, 2012

Eldepryl

Narcolepsy »

What is narcolepsy?

Narcolepsy is a chronic disease of the central nervous system. Excessive daytime sleepiness (EDS) is the main symptom and is present in 100% of patients with narcolepsy. Other primary symptoms of narcolepsy include:

loss of muscle tone (cataplexy),
distorted perceptions (hypnagogic hallucinations), and
inability to move or talk (sleep paralysis).

Additional symptoms include disturbed nocturnal sleep and automatic behavior (patients carry out certain actions without conscious awareness). All of the symptoms of narcolepsy may be present in various combinations and degrees of severity.

Narcolepsy usually begins in teenagers or young adults and affects both sexes equally. The first symptom to appear is excessive daytime sleepiness, which may remain unrecognized for a long time in that it develops gradually over time. The other symptoms can follow excessive daytime sleepiness by months...

Read the Narcolepsy article »

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Eldepryl

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PATIENT INFORMATION

Patients should be advised of the possible need to reduce levodopa dosage after the initiation of ELDEPRYL (selegiline hcl) therapy.

Patients (or their families if the patient is incompetent) should be advised not to exceed the daily recommended dose of 10 mg. The risk of using higher daily doses of selegiline should be explained, and a brief description of the 'cheese reaction' provided. Rare hypertensive reactions with selegiline at recommended doses associated with dietary influences have been reported.

Consequently, it may be useful to inform patients (or their families) about the signs and symptoms associated with MAOI induced hypertensive reactions. In particular, patients should be urged to report, immediately, any severe headache or other atypical or unusual symptoms not previously experienced.

Last reviewed on RxList: 7/15/2008
This monograph has been modified to include the generic and brand name in many instances.