home > drugs a-z list > elimite (permethrin) drug center > elimite (permethrin) drug - clinical pharmacology

Recommended Topic Related To:

Elimite

Scabies facts

  • Scabies is an itchy, highly contagious skin condition caused by an infestation by the itch mite Sarcoptes scabiei.
  • Direct skin-to-skin contact is the mode of transmission.
  • A severe and relentless itch is the predominant symptom of scabies.
  • Sexual contact is the most common form of transmission among sexually active young people, and scabies has been considered by many to be a sexually transmitted disease (STD).
  • Scabies produces a skin rash composed of small red bumps and blisters and affects specific areas of the body.
  • Treatment includes oral or topical scabicidal drugs.

What is scabies?

Scabies is an itchy, highly contagious skin disease caused by an infestation by the itch mite Sarcoptes scabiei. Mites are small eight-legged parasites (in contrast to insects, which have six legs). They are tiny, just 1/3 millimeter long, and burrow into the sk...

Elimite

font size

CLINICAL PHARMACOLOGY

Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance.

Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine. Although the amount of permethrin absorbed after a single application of the 5% Cream has not been determined precisely, data from studies with14C-labeled permethrin and absorption studies of the cream applied to patients with moderate to severe scabies indicate it is 2% or less of the amount applied.

Last reviewed on RxList: 4/30/2009
This monograph has been modified to include the generic and brand name in many instances.

Elimite - User Reviews

Elimite User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Elimite sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.