Elspar

Drug Description
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Elspar®
(asparaginase) For injection, intravenous or intramuscular

DRUG DESCRIPTION

Elspar (asparaginase) contains the enzyme L-asparagine amidohydro-lase, type EC-2, derived from Escherichia coli. Elspar activity is expressed in terms of International Units according to the recommendation of the International Union of Biochemistry. One International Unit of asparaginase is defined as that amount of enzyme required to generate 1 μmol of ammonia per minute at pH 7.3 and 37°C. The specific activity of Elspar is at least 225 International Units per milligram of protein. Elspar is provided as a sterile, white lyophilized plug or powder. Each vial contains 10, 000 International Units of asparaginase and 80 mg of mannitol.

Last updated on RxList: 10/10/2008

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