Elspar (Asparaginase) Drug Information: Overdosage and Contraindications

May 27, 2012

Leukemia is a cancer of the blood cells.
While the exact cause(s) of leukemia is not known, risk factors have been identified.
Leukemias are grouped by how quickly the disease develops (acute or chronic) as well as by the type of blood cell that is affected (lymphocytes or myelocytes). The four main types of leukemia include acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myelocytic leukemia (AML), and chronic myelocytic leukemia (CML).
People with leukemia are at significantly increased risk for developing infections, anemia, and bleeding. Other symptoms and signs include easy bruising, weight loss, night sweats, and unexplained fevers.
The diagnosis of leukemia is supported by findings of the medical history and examination, and examining blood and bone marrow samples under a microscope.
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Elspar

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Serious allergic reactions to Elspar or other Escherichia coli-derived L-asparaginases
Serious thrombosis with prior L-asparaginase therapy
Pancreatitis with prior L-asparaginase therapy
Serious hemorrhagic events with prior L-asparaginase therapy

Last reviewed on RxList: 10/10/2008
This monograph has been modified to include the generic and brand name in many instances.