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Embeda

Embeda Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking morphine and naltrexone (Embeda)?

Your dose needs may be different if you have recently used an opioid pain medicine and your body is tolerant to it. Opioid medicines include fentanyl (Actiq, Duragesic), hydromorphone (Dilaudid, Palladone), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph), oxycodone (Oxycontin), oxymorphone (Opana), and many others. Talk with your doctor if you are not sure you are opioid-tolerant.

You should not use morphine and naltrexone if you have ever had an allergic reaction to a narcotic medicine, if you are having an asthma attack or if you have a bowel obstruction called paralytic ileus.

Do not use morphine and naltrexone if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

To make sure you can safely take morphine and naltrexone, tell your doctor if you have any of these other conditions:

  • asthma, COPD, sleep apnea, or other breathing disorder;
  • liver or kidney disease;
  • low blood pressure;
  • a thyroid disorder;
  • curvature of the spine;
  • a history of head injury or brain tumor;
  • gallbladder or pancreas disorders;
  • a blockage in your stomach or intestines;
  • an adrenal gland tumor or disorder (such as Addison's disease);
  • enlarged prostate, urination problems;
  • epilepsy or other seizure disorder;
  • any type of debilitating condition;
  • mental illness; or
  • a history of alcoholism or drug addiction.

Morphine and naltrexone may be habit forming and should be used only by the person for whom it was prescribed. Never share morphine and naltrexone with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

FDA pregnancy category C. It is not known whether morphine and naltrexone will harm an unborn baby. Morphine and naltrexone may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using morphine and naltrexone.

Morphine and naltrexone can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using morphine and naltrexone.

Older adults may be more sensitive to the effects of this medicine.

How should I use morphine and naltrexone (Embeda)?

Take exactly as prescribed. Never take morphine and naltrexone in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

You may take morphine and naltrexone with or without food. Morphine and naltrexone is usually taken 1 or 2 times each day. Each dose should be spaced at least 12 hours apart. Follow your doctor's instructions.

Do not crush, chew, or dissolve the medicine pellets inside an extended-release capsule. If possible, swallow the pill whole. Crushing or chewing the medicine pellets would cause too much of the drug to be released at one time, which may cause a life-threatening overdose.

To make swallowing easier, you may open the extended-release capsule and sprinkle the medicine into a spoonful of applesauce. Mix only one dose and swallow this mixture right away without chewing. Drink a glass of water to make sure all the medicine has been swallowed. Flush the empty capsule down a toilet.

Do not stop using morphine and naltrexone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using morphine and naltrexone.

Store at room temperature away from moisture, heat, and light. Keep track of the amount of medicine used from each new bottle. Morphine and naltrexone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

After you have stopped using this medication, flush any unused pills down the toilet. Throw away any unused liquid morphine and naltrexone that is older than 90 days.

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