Emcyt
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Emcyt
SIDE EFFECTS
In a randomized, double-blind trial comparing therapy with EMCYT (estramustine) Capsules in 93 patients (11.5 to 15.9 mg/kg/day) or diethylstilbestrol (DES) in 93 patients (3.0 mg/day), the following adverse effects were reported:
| EMCYT n=93 |
DES n=93 |
|
| CARDIOVASCULAR-RESPIRATORY | ||
| Cardiac Arrest | 0 | 2 |
| Cerebrovascular Accident | 2 | 0 |
| Myocardial Infarction | 3 | 1 |
| Thrombophlebitis | 3 | 7 |
| Pulmonary Emboli | 2 | 5 |
| Congestive Heart Failure | 3 | 2 |
| Edema | 19 | 17 |
| Dyspnea | 11 | 3 |
| Leg Cramps | 8 | 11 |
| Upper Respiratory Discharge | 1 | 1 |
| Hoarseness | 1 | 0 |
| GASTROINTESTINAL | ||
| Nausea | 15 | 8 |
| Diarrhea | 12 | 11 |
| Minor Gastrointestinal Upset | 11 | 6 |
| Anorexia | 4 | 3 |
| Flatulence | 2 | 0 |
| Vomiting | 1 | 1 |
| Gastrointestinal Bleeding | 1 | 0 |
| Burning Throat | 1 | 0 |
| Thirst | 1 | 0 |
| INTEGUMENTARY | ||
| Rash | 1 | 4 |
| Pruritus | 2 | 2 |
| Dry Skin | 2 | 0 |
| Pigment Changes | 0 | 3 |
| Easy Bruising | 3 | 0 |
| Flushing | 1 | 0 |
| Night Sweats | 0 | 1 |
| Fingertip-Peeling Skin | 1 | 0 |
| Thinning Hair | 1 | 1 |
| BREAST CHANGES | ||
| Tenderness | 66 | 64 |
| Enlargement | ||
| Mild | 60 | 54 |
| Moderate | 10 | 16 |
| Marked | 0 | 5 |
| MISCELLANEOUS | ||
| Lethargy Alone | 4 | 3 |
| Depression | 0 | 2 |
| Emotional Lability | 2 | 0 |
| Insomnia | 3 | 0 |
| Headache | 1 | 1 |
| Anxiety | 1 | 0 |
| Chest Pain | 1 | 1 |
| Hot Flashes | 0 | 1 |
| Pain in Eyes | 0 | 1 |
| Tearing of Eyes | 1 | 1 |
| Tinnitus | 0 | 1 |
| LABORATORY ABNORMALITIES | ||
| Hematologic | ||
| Leukopenia | 4 | 2 |
| Thrombopenia | 1 | 2 |
| Hepatic | ||
| Bilirubin Alone | 1 | 5 |
| Bilirubin and LDH | 0 | 1 |
| Bilirubin and SGOT | 2 | 1 |
| Bilirubin, LDH and SGOT | 2 | 0 |
| LDH and/or SGOT | 31 | 28 |
| Miscellaneous | ||
| Hypercalcemia-Transient | 0 | 1 |
Read the Emcyt (estramustine) Side Effects Center for a complete guide to possible side effects »
DRUG INTERACTIONS
Food/Drug Interaction
Milk, milk products, and calcium-rich foods or drugs may impair the absorption of EMCYT (estramustine) .
Last reviewed on RxList: 8/6/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Emcyt Information
Emcyt - User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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