May 28, 2017
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"By Peter Russell
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They say the research could lead to better treatment, because doctors would be able to know which tumors are more likely to grow and spread.



Emcyt Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/1/2016

Emcyt (estramustine phosphate sodium) is an antineoplastic agent used to treat prostate cancer. Common side effects of Emcyt include:

The recommended daily dosage of Emcyt is 14 mg per kg of body weight taken in 3 to 4 divided doses at least 1 hour before or 2 hours after a meal. Tell your doctor if you have a history of stroke or heart attack, diabetes, heart disease, high blood pressure, migraine headaches, seizures, liver or kidney disease, or Paget's disease. Do not take Emcyt with any product that contains calcium such as milk. Emcyt may interact with antacids or vitamin and mineral supplements. Always use birth control while taking Emcyt as it may cause birth defects. This medication is not usually used in women and is unlikely to be used during pregnancy or breastfeeding.

Our Emcyt (estramustine phosphate sodium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Emcyt in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using estramustine and call your doctor at once if you have a serious side effect such as:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • chest pain, sudden cough, wheezing, rapid breathing, fast heart rate;
  • pain or swelling in one or both legs;
  • feeling short of breath, even with mild exertion;
  • swelling, rapid weight gain; or
  • easy bruising.

Less serious side effects may include:

  • nausea, loss of appetite, diarrhea, upset stomach;
  • feeling weak or tired;
  • breast swelling or tenderness; or
  • impotence.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Emcyt (Estramustine)

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Emcyt Overview - Patient Information: Side Effects

SIDE EFFECTS: Nausea, vomiting, loss of appetite, flushing, dry skin, headache, leg cramps, decreased sexual interest/ability, and male breast tenderness/enlargement may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., depression), swelling of hands/feet, worsening of seizures, signs of worsening diabetes control (e.g., increased thirst and urination).

This medication may infrequently cause serious problems such as heart attacks, stroke, and blood clots. Seek immediate medical attention if you experience any of the following symptoms: chest/jaw/left arm pain, sudden severe headache, weakness on one side of the body, confusion, slurred speech, sudden vision changes (e.g., double vision, loss of vision), pain/redness/swelling of legs, shortness of breath, coughing up blood, sudden dizziness/fainting.

Tell your doctor immediately if any of these rare but very serious side effects occur: easy bruising/bleeding, stomach/abdominal pain, persistent nausea/vomiting, dark urine, yellowing eyes/skin.

This medication can lower the body's ability to fight an infection. Notify your doctor promptly if you develop any signs of an infection such as fever, chills, or persistent sore throat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Emcyt (Estramustine)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Emcyt FDA Prescribing Information: Side Effects
(Adverse Reactions)


In a randomized, double-blind trial comparing therapy with EMCYT (estramustine) Capsules in 93 patients (11.5 to 15.9 mg/kg/day) or diethylstilbestrol (DES) in 93 patients (3.0 mg/day), the following adverse effects were reported:

  Cardiac Arrest 0 2
  Cerebrovascular Accident 2 0
  Myocardial Infarction 3 1
  Thrombophlebitis 3 7
  Pulmonary Emboli 2 5
  Congestive Heart Failure 3 2
  Edema 19 17
  Dyspnea 11 3
  Leg Cramps 8 11
  Upper Respiratory Discharge 1 1
  Hoarseness 1 0
  Nausea 15 8
  Diarrhea 12 11
  Minor Gastrointestinal Upset 11 6
  Anorexia 4 3
  Flatulence 2 0
  Vomiting 1 1
  Gastrointestinal Bleeding 1 0
  Burning Throat 1 0
  Thirst 1 0
  Rash 1 4
  Pruritus 2 2
  Dry Skin 2 0
  Pigment Changes 0 3
  Easy Bruising 3 0
  Flushing 1 0
  Night Sweats 0 1
  Fingertip-Peeling Skin 1 0
  Thinning Hair 1 1
  Tenderness 66 64
  Mild 60 54
  Moderate 10 16
  Marked 0 5
  Lethargy Alone 4 3
  Depression 0 2
  Emotional Lability 2 0
  Insomnia 3 0
  Headache 1 1
  Anxiety 1 0
  Chest Pain 1 1
  Hot Flashes 0 1
  Pain in Eyes 0 1
  Tearing of Eyes 1 1
  Tinnitus 0 1
  Leukopenia 4 2
  Thrombopenia 1 2
  Bilirubin Alone 1 5
  Bilirubin and LDH 0 1
  Bilirubin and SGOT 2 1
  Bilirubin, LDH and SGOT 2 0
  LDH and/or SGOT 31 28
  Hypercalcemia-Transient 0 1

Read the entire FDA prescribing information for Emcyt (Estramustine)

Emcyt - User Reviews

Emcyt User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Emcyt sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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