Emend Capsules (Aprepitant Capsules) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Emend

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Emend Capsules User Reviews >>

Emend Capsules

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EMEND
(aprepitant) Capsules

DRUG DESCRIPTION

EMEND (aprepitant) is a substance P/neurokinin 1 (NK1) receptor antagonist, chemically described as 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2dihydro-3H-1,2,4-triazol-3-one.

Its empirical formula is C₂₃H₂₁F₇N₄O₃, and its structural formula is:

EMEND (aprepitant) Structural Formula Illustration

Aprepitant is a white to off-white crystalline solid, with a molecular weight of 534.43. It is practically insoluble in water. Aprepitant is sparingly soluble in ethanol and isopropyl acetate and slightly soluble in acetonitrile.

Each capsule of EMEND (aprepitant capsules) for oral administration contains either 40 mg, 80 mg, or 125 mg of aprepitant and the following inactive ingredients: sucrose, microcrystalline cellulose, hydroxypropyl cellulose and sodium lauryl sulfate. The capsule shell excipients are gelatin, titanium dioxide, and may contain sodium lauryl sulfate and silicon dioxide. The 40-mg capsule shell also contains yellow ferric oxide, and the 125-mg capsule also contains red ferric oxide and yellow ferric oxide.

What are the possible side effects of aprepitant (Emend, Emend 3-Day)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

feeling light-headed, fainting;
slow heart rate;
pale skin, easy bruising or bleeding; or
pain or burning when you urinate.

Less serious side effects may include:

nausea, vomiting, heartburn, stomach pain;

Read All Potential Side Effects and See Pictures of Emend Capsules »

What are the precautions when taking aprepitant capsules (Emend Capsules)?

Before using aprepitant, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this drug passes into breast milk. Consult your doctor before...

Read All Potential Precautions of Emend Capsules »

Last reviewed on RxList: 4/12/2010
This monograph has been modified to include the generic and brand name in many instances.