"Fosaprepitant dimeglumine (Emend, Merck) is now approved in the United States as a single-use injection to prevent delayed nausea and vomiting in adults receiving initial and repeat courses of moderately emetogenic chemotherapy (MEC); it"...
Emend Capsules Consumer (continued)
Some products that may interact with this drug include: cisapride, drugs affecting liver enzymes that remove aprepitant from your body (such as azole antifungals including itraconazole, macrolide antibiotics including erythromycin, cimetidine, rifamycins including rifabutin, St. John's wort, certain anti-seizure medicines including carbamazepine/phenytoin, certain cancer chemotherapy drugs including ifosfamide/vinblastine/vincristine), pimozide.
Aprepitant can both speed up and slow down the removal of other drugs from your body, thereby affecting how they work. These affected drugs include (not a complete list): benzodiazepines (e.g., alprazolam, midazolam, triazolam), simvastatin, drugs to treat erectile dysfunction-ED or pulmonary hypertension (e.g., sildenafil, tadalafil).
If you take warfarin, this drug may affect how well warfarin works in your body. Therefore, your doctor should test your blood during the 2 weeks after your aprepitant treatment to measure how well warfarin is working.
This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication and for 1 month after stopping this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.
Aprepitant is very similar to fosaprepitant. Do not use fosaprepitant while using aprepitant.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.
MISSED DOSE: It is important that you take each dose according to the prescribed schedule. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule.
STORAGE: Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised March 2014. Copyright(c) 2014 First Databank, Inc.
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