"Fosaprepitant dimeglumine (Emend, Merck) is now approved in the United States as a single-use injection to prevent delayed nausea and vomiting in adults receiving initial and repeat courses of moderately emetogenic chemotherapy (MEC); it"...
No specific information is available on the treatment of overdosage.
Drowsiness and headache were reported in one patient who ingested 1440 mg of EMEND (approximately 11 times the maximum recommended single dose).
In the event of overdose, EMEND should be discontinued and general supportive treatment and monitoring should be provided. Because of the antiemetic activity of EMEND, drug-induced emesis may not be effective in cases of EMEND overdosage.
Aprepitant is not removed by hemodialysis.
EMEND is contraindicated in patients:
- who are hypersensitive to any component of the product. Hypersensitivity reactions including anaphylactic reactions have been reported [see ADVERSE REACTIONS].
- taking pimozide. Inhibition of CYP3A4 by aprepitant could result in elevated plasma concentrations of this drug which is a CYP3A4 substrate, potentially causing serious or life-threatening reactions, such as QT prolongation, a known adverse reaction of pimozide [see WARNINGS AND PRECAUTIONS].
Last reviewed on RxList: 12/26/2015
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