Emend Capsules (Aprepitant Capsules) Drug Information: Overdosage and Contraindications

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May 27, 2012

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Nausea and Vomiting »

Nausea and vomiting facts

Nausea and vomiting are symptoms of a disease or condition. The underlying cause of the illness causing nausea and vomiting should be identified and treated.
Nausea and vomiting symptom control is important both for comfort's sake and to prevent dehydration.
Dehydration can worsen nausea and vomiting.
Medication may be available to control symptoms of nausea and vomiting.

Introduction to nausea and vomiting

Nausea and vomiting are symptoms of an underlying illness and not a specific disease. Nausea is the sensation that the stomach wants to empty itself, while vomiting (emesis) or throwing up, is the act of forcible emptying of the stomach. The term "dry heaves" refers to an episode of vomiting where there is no food in the stomach to vomit, and only clear secretions are vomited.

Vomiting is a violent act in which the stomach almost...

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OVERDOSE

No specific information is available on the treatment of overdosage.

Drowsiness and headache were reported in one patient who ingested 1440 mg of aprepitant.

In the event of overdose, EMEND (aprepitant capsules) should be discontinued and general supportive treatment and monitoring should be provided. Because of the antiemetic activity of aprepitant, drug-induced emesis may not be effective.

Aprepitant cannot be removed by hemodialysis.

CONTRAINDICATIONS

EMEND (aprepitant capsules) is contraindicated in patients who are hypersensitive to any component of the product.

EMEND (aprepitant capsules) is a dose-dependent inhibitor of cytochrome P450 isoenzyme 3A4 (CYP3A4). EMEND (aprepitant capsules) should not be used concurrently with pimozide, terfenadine, astemizole, or cisapride. Inhibition of CYP3A4 by aprepitant could result in elevated plasma concentrations of these drugs, potentially causing serious or life-threatening reactions [see DRUG INTERACTIONS].

Last reviewed on RxList: 4/12/2010
This monograph has been modified to include the generic and brand name in many instances.