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(fosaprepitant dimeglumine) for Injection
EMEND (fosaprepitant dimeglumine) for injection is a sterile, lyophilized prodrug of aprepitant, a substance P/neurokinin-1 (NK 1) receptor antagonist, an antiemetic agent, chemically described as 1Deoxy-1-(methylamino)-D-glucitol[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1) (salt).
Its empirical formula is C23H22F7N4O6P • 2(C7H17NO5) and its structural formula is:
Fosaprepitant dimeglumine is a white to off-white amorphous powder with a molecular weight of 1004.83. It is freely soluble in water.
Each vial of EMEND for injection for administration as an intravenous infusion contains 245.3 mg of fosaprepitant dimeglumine equivalent to 150 mg of fosaprepitant free acid and the following inactive ingredients: edetate disodium (18.8 mg), polysorbate 80 (75 mg), lactose anhydrous (375 mg), sodium hydroxide and/or hydrochloric acid (for pH adjustment). Fosaprepitant dimeglumine hereafter will be referred to as fosaprepitant.
What are the possible side effects of fosaprepitant (Emend for Injection)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:
- feeling light-headed, fainting;
- slow heart rate;
- pale skin, easy bruising or bleeding; or
- pain or burning when you urinate.
Less serious side effects may include:
- nausea, vomiting, heartburn, stomach pain;
- diarrhea or constipation;
- loss of...
What are the precautions when taking fosaprepitant dimeglumine injection (Emend Injection)?
Before using fosaprepitant, tell your doctor or pharmacist if you are allergic to it; or to aprepitant; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is not known if this drug passes into breast milk. Consult your doctor before...
Last reviewed on RxList: 2/16/2016
This monograph has been modified to include the generic and brand name in many instances.
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