"The immunotherapy pembrolizumab (Keytruda, Merck & Co) has been approved for use in the treatment of head and neck cancer by the US Food and Drug Administration (FDA).
This is the third cancer indication for the drug; it "...
Emend Injection Consumer (continued)
Some products that may interact with this drug include: cisapride, drugs affecting liver enzymes that remove fosaprepitant from your body (such as azole antifungals including itraconazole, macrolide antibiotics including erythromycin, cimetidine, rifamycins including rifabutin, St. John's wort, certain anti-seizure medicines including carbamazepine/phenytoin, certain cancer chemotherapy drugs including ifosfamide/vinblastine/vincristine), pimozide.
Fosaprepitant can both speed up and slow down the removal of other drugs from your body, thereby affecting how they work. These affected drugs include (not a complete list): benzodiazepines (e.g., alprazolam, midazolam, triazolam), simvastatin, drugs to treat erectile dysfunction-ED or pulmonary hypertension (e.g., sildenafil, tadalafil).
If you take warfarin, this drug may affect how well warfarin works in your body. Therefore, your doctor should test your blood during the 2 weeks after your fosaprepitant treatment to measure how well warfarin is working.
This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication and for 1 month after the last dose of this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.
Fosaprepitant is very similar to aprepitant. Do not take medications containing aprepitant while using fosaprepitant.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Not applicable.
MISSED DOSE: It is important that you receive the dose before cancer chemotherapy as directed by your doctor. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule.
STORAGE: Not applicable. This medication is given in a clinic and will not be stored at home.
Information last revised March 2014. Copyright(c) 2014 First Databank, Inc.
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