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Brand Names: Emend for Injection

Generic Name: fosaprepitant (Pronunciation: FOS a PREP i tan t)

• What is fosaprepitant (Emend Injection)?
• What are the possible side effects of fosaprepitant (Emend Injection)?
• What is the most important information I should know about fosaprepitant (Emend Injection)?
• What should I discuss with my health care provider before I receive fosaprepitant (Emend Injection)?
• How is fosaprepitant given (Emend Injection)?
• What happens if I miss a dose (Emend Injection)?
• What happens if I overdose (Emend Injection)?
• What should I avoid while receiving fosaprepitant (Emend Injection)?
• What other drugs will affect fosaprepitant (Emend Injection)?
• Where can I get more information?

What is fosaprepitant (Emend Injection)?

Fosaprepitant blocks the actions of chemicals in the body that trigger nausea and vomiting.

Fosaprepitant is used together with other medications to prevent nausea and vomiting that may be caused by cancer chemotherapy.

Fosaprepitant is given ahead of time and will not treat nausea or vomiting that you already have.

Fosaprepitant may also be used for other purposes not listed in this medication guide.

What are the possible side effects of fosaprepitant (Emend Injection)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

• feeling light-headed, fainting;
• slow heart rate;
• pale skin, easy bruising or bleeding; or
• pain or burning when you urinate.

Less serious side effects may include:

• nausea, vomiting, heartburn, stomach pain;
• diarrhea or constipation;
• loss of appetite;
• hiccups;
• increased thirst or hot, dry skin;
• weakness, dizziness, tired feeling;
• headache;
• ringing in your ears;
• fever, chills, body aches, flu symptoms;
• sleep problems (insomnia); or
• pain or a hard lump where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about fosaprepitant (Emend Injection)?

You should not receive fosaprepitant if you are taking cisapride (Propulsid) or pimozide (Orap). These drugs may cause life-threatening interactions when taken together with fosaprepitant.

Before you receive fosaprepitant, tell your doctor if you have liver disease. You may need a dose adjustment or special tests to safely use this medication.

Fosaprepitant can make birth control pills less effective, resulting in pregnancy. This effect can last for up to 28 days after your last dose of this medication. Talk to your doctor about the use of a non-hormonal back-up form of birth control (such as condoms, a diaphragm, or spermicides) during treatment with fosaprepitant, and for 1 month afterward.

There are many other medicines that can interact with fosaprepitant. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.