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Empirin Codeine

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Empirin Codeine

Empirin Codeine Patient Information including If I Miss a Dose

What happens if I miss a dose (Empirin Codeine)?

Since aspirin and codeine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose (Empirin Codeine)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of aspirin and codeine can be fatal.

Overdose symptoms may include extreme dizziness or spinning sensation, sweating, pinpoint pupils, double vision, vomiting, hallucinations, muscle weakness or limp feeling, cold and clammy skin, fainting, weak pulse, seizure (convulsions), blue lips, shallow breathing, or no breathing.

What should I avoid while taking aspirin and codeine (Empirin Codeine)?

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how aspirin and codeine will affect you.

Ask a doctor or pharmacist before using any other over-the-counter cold, allergy, or pain medicine. Aspirin is contained in many combination medicines. Taking certain products together can cause you to get too much aspirin. Check the label to see if a medicine contains aspirin.

Avoid taking acetaminophen (Tylenol) or an NSAID while you are taking aspirin and codeine, unless your doctor tells you to. NSAIDs include ibuprofen (Advil, Motrin), ketorolac (Toradol), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

Avoid drinking alcohol. It may increase your risk of stomach bleeding while taking aspirin.

What other drugs will affect aspirin and codeine (Empirin Codeine)?

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy or could slow your breathing (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by aspirin and codeine.

Many drugs can interact with aspirin and codeine. Below is just a partial list. Tell your doctor if you are using:

  • deferasirox (Exjade);
  • leflunomide (Arava);
  • methotrexate (Rheumatrex, Trexall);
  • sirolimus (Rapamune) or tacrolimus (Prograf);
  • an antidepressant, such as bupropion (Wellbutrin, Zyban), citalopram (Celexa), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), and others;
  • antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or tenofovir (Viread, Atripla, Complera, Truvada);
  • aspirin or other salicylates, including Kaopectate, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others;
  • bowel cleansing preparations (Half Lytely, Fleet Prep Kit, Evac-Q-Kwik, GoLytely, Supraprep, and others);
  • glaucoma medication such as acetazolamide (Diamox) or methazolamide (Glauctabs, Neptazane); or
  • medication used to prevent blood clots, such as dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), tinzaparin (Innohep), and others.

This list is not complete and other drugs may interact with aspirin and codeine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about aspirin and codeine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 6.01. Revision date: 8/28/2012.

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