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Empirin Codeine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Empirin Codeine (aspirin and codeine) is used to treat moderate to severe pain. Codeine is a narcotic pain reliever, and aspirin is a less potent pain reliever and is also a fever reducer. This medication is available in generic form. Common side effects include constipation, nausea, vomiting, dizziness, tired feeling, headache, sweating, increased thirst, or mild skin rash.
The usual adult dose for Aspirin and Codeine 30 mg is one or two tablets every four hours as needed. The usual adult dose for Aspirin and Codeine 60 mg is one tablet every four hours as needed. Empirin Codeine may interact with glycopyrrolate, mepenzolate, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bladder or urinary medications, bronchodilators, or irritable bowel medications. Tell your doctor all medications you use. During pregnancy, Empirin Codeine should be used only if prescribed. It may be harmful to a fetus, and could cause breathing problems or addiction/withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Aspirin and codeine can pass into breast milk and may harm a nursing baby. The use of codeine by some nursing mothers may lead to life-threatening side effects in the baby. Consult your doctor before breast-feeding. Codeine may be habit-forming. Withdrawal symptoms may occur if you suddenly stop taking this medication.
Our Empirin Codeine (aspirin and codeine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Empirin Codeine in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- black, bloody, or tarry stools;
- coughing up blood or vomit that looks like coffee grounds;
- dizziness, feeling like you might pass out;
- severe nausea, vomiting, or stomach pain;
- swelling, or pain lasting longer than 10 days;
- shallow breathing, fast or slow heartbeat;
- feeling light-headed, fainting;
- pale skin, easy bruising or bleeding;
- wheezing, chest tightness, trouble breathing;
- decreased hearing or ringing in the ears;
- seizure (convulsions); or
- dizziness, confusion, unusual thoughts or behavior.
Less serious side effects may include:
- nausea, vomiting;
- dizziness, tired feeling;
- increased thirst; or
- mild skin rash.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Empirin Codeine (Aspirin and Codeine) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Empirin Codeine Overview - Patient Information: Side Effects
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Empirin Codeine (Aspirin and Codeine)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Empirin Codeine FDA Prescribing Information: Side Effects
The most frequently observed adverse reactions to codeine include light-headedness, dizziness, drowsiness, nausea, vomiting, constipation and depression of respiration. Less common reactions to codeine include euphoria, dysphoria, pruritus and skin rashes.
Mild aspirin intoxication (salicylism) can occur in response to chronic use of large doses. Manifestations include nausea, vomiting, hearing impairment, tinnitus, diminished vision, headache, dizziness, drowsiness, mental confusion, hyperpnea, hyperventilation, tachycardia, sweating and thirst.
Therapeutic doses of aspirin can induce mild or severe allergic reactions manifested by skin rashes, urticaria, angioedema, rhinorrhea, asthma, abdominal pain, nausea, vomiting, or anaphylactic shock. A history of allergy is often lacking, and allergic reactions may occur even in patients who have previously taken aspirin without any ill effects. Allergic reactions to aspirin are most likely to occur in patients with a history of allergic disease, especially in patients with nasal polyps or asthma.
Some patients are unable to take aspirin or other salicylates without developing nausea or vomiting. Occasional patients respond to aspirin (usually in large doses) with dyspepsia or heartburn, which may be accompanied by occult bleeding. Excessive bruising or bleeding is sometimes seen in patients with mild disorders of primary hemostasis who regularly use low doses of aspirin.
Prolonged use of aspirin can cause painless erosion of gastric mucosa, occult bleeding and infrequently, iron-deficiency anemia. High doses of aspirin can exacerbate symptoms of peptic ulcer and occasionally, cause extensive bleeding.
Excessive bleeding can follow injury or surgery in patients with or without known bleeding disorders who have taken therapeutic doses of aspirin within the preceding 10 days. Hepatotoxicity has been reported in association with prolonged use of large doses of aspirin in patients with lupus erythematosus, rheumatoid arthritis and rheumatic disease. Bone marrow depression, manifested by weakness, fatigue, or abnormal bruising or bleeding, has occasionally been reported. In patients with glucose-6-phosphate dehydrogenase deficiency, aspirin can cause a mild degree of hemolytic anemia. In hyperuricemic persons, low doses of aspirin may reduce the effectiveness of uricosuric therapy or precipitate an attack of gout.
DRUG ABUSE AND DEPENDENCE
Like other medications containing a narcotic analgesic, aspirin and codeine (aspirin and codeine (aspirin and codeine) ) phosphate tablets are controlled by the Drug Enforcement Administration and is classified under Schedule III.
Aspirin and codeine (aspirin and codeine (aspirin and codeine) ) can produce drug dependence of the morphine type; therefore, it has a potential for being abused. Psychic dependence, physical dependence and tolerance may develop on repeated administration.
The dependence liability of codeine has been found to be too small to permit a full definition of its characteristics. Studies indicate that addiction to codeine is extremely uncommon and requires very high parenteral doses.
When dependence on codeine occurs at therapeutic doses, it appears to require from one to two months to develop, and withdrawal symptoms are mild. Most patients on long-term oral codeine therapy show no signs of physical dependence upon abrupt withdrawal.
Read the entire FDA prescribing information for Empirin Codeine (Aspirin and Codeine) »
Additional Empirin Codeine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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