Enablex (Darifenacin Extended-Release Tablets) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Enablex

Overactive Bladder »

What is an overactive bladder?

An overactive bladder is a condition that results from sudden, involuntary contraction of the muscle in the wall of the urinary bladder. Overactive bladder causes a sudden and unstoppable need to urinate (urinary urgency), even though the bladder may only contain a small amount of urine.

Overactive bladder is also referred to as urge incontinence and is a form of urinary incontinence (unintentional loss of urine). Another common type of urinary incontinence is called stress incontinence, which is caused by anatomic weakness in the structures that prevent the bladder from leaking. In general, urinary incontinence is more common in women compared to men.

Although it can happen at any age, overactive bladder is especially common in older adults. Overactive bladder affects an estimated one in 11 adults in the United States. Overactive bladder, however, should not be considered a normal part of aging.

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Read the Overactive Bladder article »

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ENABLEX ®
(darifenacin)

DRUG DESCRIPTION

Enablex is an extended-release tablet for oral administration which contains 7.5 mg or 15 mg darifenacin as its hydrobromide salt. The active moiety, darifenacin, is a potent muscarinic receptor antagonist.

Chemically, darifenacin hydrobromide is (S)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2diphenylacetamide hydrobromide. The empirical formula of darifenacin hydrobromide is C₂₈H₃₀N₂O₂•HBr. The structural formula is:

ENABLEX® (darifenacin) Structural Formula Illustration

Darifenacin hydrobromide is a white to almost white, crystalline powder, with a molecular weight of 507.5.

Enablex is a once-a-day extended-release tablet and contains the following inactive ingredients: dibasic calcium phosphate anhydrous, hypromellose, magnesium stearate, polyethylene glycol, talc, titanium dioxide. The 15 mg tablet also contains iron oxide red and iron oxide yellow.

What are the possible side effects of darifenacin (Enablex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using darifenacin and call your doctor at once if you have any of these serious side effects:

hot, dry skin and extreme thirst;
severe stomach pain or constipation;
pain or burning when you urinate; or
urinating less than usual or not at all.

Less serious side effects may include:

dry...

Read All Potential Side Effects and See Pictures of Enablex »

What are the precautions when taking darifenacin extended-release tablets (Enablex)?

Before taking darifenacin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: problems emptying your bladder (urinary retention), severe blockage of stomach/intestines (gastric retention), a certain eye condition (uncontrolled narrow angle glaucoma), severe liver disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other bladder problems (e.g., bladder outflow obstruction),...

Read All Potential Precautions of Enablex »

Last reviewed on RxList: 3/22/2012
This monograph has been modified to include the generic and brand name in many instances.