Enablex (Darifenacin Extended-Release Tablets) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 16, 2012

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Urinary Incontinence in Women »

Urinary incontinence (UI) in women facts

*Urinary incontinence (UI) in men facts Medically Edited by: Melissa Conrad Stöppler, MD

The definition of urinary incontinence in women is the unintentional loss of urine.
Urinary incontinence occurs more often in women than in men. Pregnancy, childbirth, and menopause may contribute to urinary incontinence in women.
Weak bladder muscles, overactive bladder muscles, and nerve damage may also cause urinary incontinence in women.
Urinary incontinence in women is common and treatable.
There are different types of urinary incontinence in women, including stress incontinence, urge incontinence, overactive bladder, functional incontinence, overflow incontinence, mixed incontinence, and transient incontinence.
Diagnosis of urinary incontinence in women may involve a physical exam, an ultrasound, urodynamic testing, and tests including cystoscopy, urinalysis, and a bl...

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ENABLEX ®
(darifenacin)

DRUG DESCRIPTION

Enablex is an extended-release tablet for oral administration which contains 7.5 mg or 15 mg darifenacin as its hydrobromide salt. The active moiety, darifenacin, is a potent muscarinic receptor antagonist.

Chemically, darifenacin hydrobromide is (S)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2diphenylacetamide hydrobromide. The empirical formula of darifenacin hydrobromide is C₂₈H₃₀N₂O₂•HBr. The structural formula is:

ENABLEX® (darifenacin) Structural Formula Illustration

Darifenacin hydrobromide is a white to almost white, crystalline powder, with a molecular weight of 507.5.

Enablex is a once-a-day extended-release tablet and contains the following inactive ingredients: dibasic calcium phosphate anhydrous, hypromellose, magnesium stearate, polyethylene glycol, talc, titanium dioxide. The 15 mg tablet also contains iron oxide red and iron oxide yellow.

What are the possible side effects of darifenacin (Enablex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using darifenacin and call your doctor at once if you have any of these serious side effects:

hot, dry skin and extreme thirst;
severe stomach pain or constipation;
pain or burning when you urinate; or
urinating less than usual or not at all.

Less serious side effects may include:

dry...

Read All Potential Side Effects and See Pictures of Enablex »

What are the precautions when taking darifenacin extended-release tablets (Enablex)?

Before taking darifenacin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: problems emptying your bladder (urinary retention), severe blockage of stomach/intestines (gastric retention), a certain eye condition (uncontrolled narrow angle glaucoma), severe liver disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other bladder problems (e.g., bladder outflow obstruction),...

Read All Potential Precautions of Enablex »

Last reviewed on RxList: 3/22/2012
This monograph has been modified to include the generic and brand name in many instances.