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Enalaprilat

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Enalaprilat Injection

ENALAPRILAT
Injection

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, enalaprilat injection should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

DRUG DESCRIPTION

Enalaprilat injection is a sterile aqueous solution for intravenous administration. Enalaprilat is an angiotensin converting enzyme inhibitor. It is chemically described as 1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline dihydrate. Its molecular formula is C18H24N205•2H2O and its structural formula is:

Enalaprilat structural formula illustration

Enalaprilat is a white to off-white, crystalline powder with a molecular weight of 384.43. It is sparingly soluble in methanol and slightly soluble in water.

Each milliliter of enalaprilat injection contains 1.25 mg enalaprilat (anhydrous equivalent); sodium chloride to adjust tonicity; sodium hydroxide to adjust pH; water for injection, q.s.; with benzyl alcohol, 9 mg, added as a preservative.

Last reviewed on RxList: 9/19/2007
This monograph has been modified to include the generic and brand name in many instances.

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