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Instructions for Use


The Enbrel SureClick autoinjector is a single-use prefilled autoinjector. It contains one 50-mg dose of Enbrel.

Your healthcare provider has prescribed Enbrel SureClick autoinjector for your injections. If your healthcare provider decides that you or a caregiver may be able to give your injections of Enbrel at home, you should receive training on the right way to prepare and inject Enbrel. Do not try to inject yourself until you have been shown the right way to give the injections by your healthcare provider.

Please read all of the instructions before using Enbrel SureClick autoinjector. Call your healthcare provider if you or your caregiver has any questions about the right way to inject Enbrel.

Instructions for Use


Solution for Subcutaneous Use

Single-Use Prefilled SureClick® Autoinjector

Guide to parts

Before use

Before use - Illustration

After use

After use - Illustration

Important: Needle is inside


Before you use an Enbrel SureClick autoinjector, read this important information:

Storing your Enbrel SureClick autoinjectors

  • Keep the Enbrel SureClick autoinjector and all medicines out of the reach of children.
  • Keep the Enbrel SureClick autoinjector in the original carton to protect from light or physical damage.
  • The Enbrel SureClick autoinjector should be kept in the refrigerator (36°F to 46°F [2°C to 8°C]).
  • If needed, you may store the Enbrel SureClick autoinjector at room temperature at 68°F to 77°F (20°C to 25°C) for up to 14 days. Throw away Enbrel that has been stored at room temperature after 14 days.
  • Do not store the Enbrel SureClick autoinjector in extreme heat or cold. For example, avoid storing in your vehicle's glove box or trunk. Do not freeze.

Using your Enbrel SureClick autoinjector

  • It is important that you do not try to give the injection unless you or your caregiver has received training from your healthcare provider.
  • Do not use an Enbrel SureClick autoinjector after the expiration date on the label.
  • Do not shake the Enbrel SureClick autoinjector.
  • Do not remove the white cap from the Enbrel SureClick autoinjector until you are ready to inject.
  • Do not use an Enbrel SureClick autoinjector if it has been dropped on a hard surface. Part of the Enbrel SureClick autoinjector may be broken even if you cannot see the break. Use a new Enbrel SureClick autoinjector, and call 1-888-4ENBREL (1-888-436-2735). This product contains dry natural rubber, which is made from latex, within the white cap. Tell your healthcare provider if you are allergic to latex.
  • Children must weigh at least 138 pounds to use the Enbrel SureClick autoinjector. Children who weigh less than 138 pounds should use a different form of Enbrel.

For more information or help, visit www.enbrel.com or call 1-888-4ENBREL (1-888-436-2735).

Step 1: Prepare

A. Remove one Enbrel SureClick autoinjector from the package.

Carefully lift the autoinjector straight up out of the box.

Put the original package with any unused autoinjectors back in the refrigerator.

Leave the autoinjector at room temperature for at least 30 minutes before injecting.

  • Do not put the autoinjector back in the refrigerator once it has reached room temperature.
  • Do not try to warm the autoinjector by using a heat source such as hot water or microwave.
  • Do not shake the autoinjector.
  • Do not remove the white cap from the autoinjector yet.

B. Inspect the Enbrel SureClick autoinjector.

Inspect the Enbrel SureClick autoinjector - Illustration

Make sure the medicine in the window is clear and colorless.

It is okay if you see small white particles in the medicine

  • Do not use the autoinjector if:
    • The medicine is cloudy or discolored or contains large lumps, flakes, or colored particles.
    • Any part appears cracked or broken.
    • The white cap is missing or not securely attached.
    • The expiration date printed on the label has passed.

In all cases, use a new autoinjector, and call 1-888-4ENBREL (1-888-436-2735).

C. Gather all materials needed for your injection.

Wash your hands thoroughly with soap and water. On a clean, well-lit work surface, place the:

  • New autoinjector
  • Alcohol wipes
  • Cotton ball or gauze pad
  • Adhesive bandage
  • Sharps disposal container

Materials needed for your injection - Illustration

D. Prepare and clean your injection site.

Recommended injection site - Illustration

You can use:

  • Your thigh
  • Stomach area (abdomen), except for a 2-inch area right around your navel
  • Outer area of upper arm (only if someone else is giving you the injection)

Clean your injection site with an alcohol wipe. Let your skin dry.

  • Do not touch this area again before injecting.
  • Choose a different site each time you give yourself an injection. If you need to use the same injection site, just make sure it is not the same spot on that site you used last time.
    • Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid injecting into areas with scars or stretch marks.
  • If you have psoriasis, you should avoid injecting directly into raised, thick, red, or scaly skin patch or lesion.

Step 2: Get ready

E. Pull white cap straight off when you are ready to inject.

Pull white cap straight off - Illustration

It is normal to see a drop of liquid at the end of the needle or green safety guard.

  • Do not twist or bend the white cap.
  • Do not put the white cap back onto the autoinjector.
  • Do not remove the white cap from the autoinjector until you are ready to inject.

F. Stretch or pinch your injection site to create a firm surface.

Stretch method

Stretch method - Illustration

Stretch skin firmly by moving your thumb and fingers in opposite directions, creating an area about 2 inches wide.


Pinch method

Pinch method -  Illustration

Pinch skin firmly between your thumb and fingers, creating an area about 2 inches wide.

Important: Keep skin stretched or pinched while injecting.

Step 3: Inject

G. Hold the stretch or pinch. With the white cap off, place the autoinjector on your skin at 90 degrees.

place the autoinjector on your skin at 90 degrees - Illustration

Important: Do not touch the purple start button yet.

H. Firmly push the autoinjector down onto skin until it stops moving.

Firmly push the autoinjector down - Illustration

Important: You must push all the way down but do not touch purple start button until you are ready to inject.

I. When you are ready to inject, press the purple start button.

Press the purple start button - Illustration

J. Keep pushing down on your skin. Your injection could take about 15 seconds.

Keep pushing down - Illustration

Note: After you remove autoinjector from your skin, the needle will be automatically covered.

Needle will be automatically covered - Illustration

Important: When you remove the autoinjector, if the window has not turned yellow, or if it looks like the medicine is still injecting, this means you have not received a full dose. Call your healthcare provider immediately.

Step 4: Finish

K. Discard the used autoinjector and the white cap.

Discard the used autoinjector and the white cap - Illustration


  • Put the used SureClick Autoinjector in a FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) the SureClick Autoinjector in your household trash.
  • If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:
    • made of a heavy-duty plastic,
    • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
    • upright and stable during use,
    • leak-resistant, and
    • properly labeled to warn of hazardous waste inside the container.
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA's website at: http://www.fda.gov/safesharpsdisposal
  • Do not reuse the autoinjector.
  • Do not recycle the autoinjector or sharps disposal container or throw them into household trash.

Important: Always keep the sharps disposal container out of the reach of children.

L. Examine the injection site.

If there is blood, press a cotton ball or gauze pad on your injection site. Do not rub the injection site. Apply an adhesive bandage if needed.

Please see the Medication Guide for Enbrel and accompanying Prescribing Information.

Commonly asked questions

What will happen if I press the purple start button before I am ready to do the injection on my skin?

Even when you press the purple start button, the injection will only happen when the green safety guard is also pushed into the autoinjector.

Can I move the autoinjector around on my skin while I am choosing an injection site?

It is okay to move the autoinjector around on the injection site as long as you do not press the purple start button. However, if you press the purple start button and the green safety guard is pushed into the autoinjector, the injection will begin.

Can I release the purple start button after I start my injection?

You can release the purple start button, but continue to hold the autoinjector firmly against your skin during the injection.

Will the purple start button pop up after I release my thumb?

The purple start button may not pop up after you release your thumb if you held your thumb down during the injection. This is okay.

What do I do if I didn’t hear a click after pushing the device down on my skin for 15 seconds?

If you didn't hear a click, you can confirm a complete injection by checking that the window has turned yellow.

Whom do I contact if I need help with the autoinjector or my injection?

If you have any questions about the autoinjector, its storage, or about your injection, visit www.enbrel.com or call 1-888-4ENBREL (1-888-436-2735) for help.

Last reviewed on RxList: 4/6/2015
This monograph has been modified to include the generic and brand name in many instances.

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