Endometrin (Progesterone) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

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Endometrin

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Endometrin®
(progesterone) Vaginal Insert

DRUG DESCRIPTION

Endometrin (progesterone) Vaginal Insert contains micronized progesterone. Endometrin (progesterone) is supplied with polyethylene vaginal applicators.

The active ingredient, progesterone, is present in 100 mg amount along with other excipients. The chemical name for progesterone is pregn-4-ene-3, 20-dione. It has an empirical formula of C₂₁H₃₀O₂ and a molecular weight of 314.5. Progesterone exists in two polymorphic forms. The form used in Endometrin (progesterone) , the alpha-form, has a melting point of 127-131°C.

The structural formula is:

Endometrin® (progesterone)) Structural Formula Illustration

Each Endometrin Vaginal Insert delivers 100 mg of progesterone in a base containing lactose monohydrate, polyvinylpyrrolidone, adipic acid, sodium bicarbonate, sodium lauryl sulfate, magnesium stearate, pregelatinized starch, and colloidal silicone dioxide.

What are the precautions when taking progesterone (Endometrin)?

Before using progesterone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of blood clots, recent stroke or heart attack (within 1 year), liver disease, cancer of the breast or other female organs, vaginal bleeding of unknown cause, a loss of pregnancy with some tissue remaining in the uterus ("missed abortion"), an abnormal pregnancy where the fertilized egg is outside of the uterus (ectopic pregnancy).

Before using this...

Read All Potential Precautions of Endometrin »

Last reviewed on RxList: 4/4/2008
This monograph has been modified to include the generic and brand name in many instances.