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Endrate (Edetate Disodium Injection, USP) is a sterile, nonpyrogenic, concentrated solution of edetate disodium in water for injection which as a result of a pH adjustment with sodium hydroxide contains varying amounts of disodium and trisodium salts. After dilution, it is administered by intravenous infusion.

Each mL contains edetate disodium, anhydrous 150 mg. May contain sodium hydroxide for pH adjustment. pH is 7.0 (6.5 to 7.5). Edetate disodium is classified as a clinical chelating agent for emergency lowering of serum calcium in hypercalcemia. The solution contains no bacteriostat, antimicrobial agent or buffer (except for pH adjustment) and is intended only for use (after dilution) as a single-dose infusion. When smaller doses are required, the unused portion should be discarded.

Edetate Disodium, USP is chemically designated disodium (ethylenedinitrilo) tetraacetate dihydrate, a white crystalline powder soluble in water. It is also described as the disodium salt of ethylenediamine tetraacetic acid (EDTA) and has the following structural formula:

Last reviewed on RxList: 5/27/2009
This monograph has been modified to include the generic and brand name in many instances.