"March 11, 2013 (San Francisco) -- Hardening of the arteries may not be such a modern problem after all.
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- Clinician Information:
Endrate Patient Information including How Should I Take
In this Article
- What is edetate disodium (Endrate)?
- What are the possible side effects of edetate disodium (Endrate)?
- What is the most important information I should know about edetate disodium (Endrate)?
- What should I discuss with my health care provider before receiving edetate disodium (Endrate)?
- How is edetate disodium given (Endrate)?
- What happens if I miss a dose (Endrate)?
- What happens if I overdose (Endrate)?
- What should I avoid after receiving edetate disodium (Endrate)?
- What other drugs will affect edetate disodium (Endrate)?
- Where can I get more information?
What should I discuss with my health care provider before receiving edetate disodium (Endrate)?
You should not receive this medication if you are unable to urinate, or if you have arteriosclerosis (hardening of the arteries).
If possible, before you receive EDTA, tell your doctor if you are allergic to any drugs, or if you have:
- heart disease, congestive heart failure;
- a heart rhythm disorder;
- a history of seizures, brain tumor, or head injury;
- low potassium levels (hypokalemia); or
- if you take digitalis (digoxin, Lanoxin, Lanoxicaps).
If you have any of these conditions, you may not be able to receive EDTA, or you may need dosage adjustments or special tests during treatment.
FDA pregnancy category C. This medication may be harmful to an unborn baby. If possible, tell your doctor if you are pregnant before you receive EDTA.
It is not known whether EDTA passes into breast milk or if it could harm a nursing baby. If possible, tell your doctor if you are breast-feeding a baby.
In an emergency situation, it may not be possible before you are treated with EDTA to tell your caregivers if you are pregnant or breast-feeding. However, make sure any doctor caring for your pregnancy or your baby knows that you have received this medication.
How is edetate disodium given (Endrate)?
EDTA is given as an injection through a needle placed into a vein. You will receive this injection in a hospital or emergency setting. The medicine must be given slowly through an IV infusion, and can take at least 3 hours to complete.
EDTA is usually given for 5 days in a row, followed by 1 day off the medicine. This schedule is then repeated for as long as needed until blood calcium levels are lowered to a safe level.
After you receive EDTA, you will need to remain lying down for a short time. Reversing high blood levels of calcium can cause a drop in your blood pressure. This can make you feel very light-headed or slow your breathing. You will need to be watched closely for these and other effects after you receive the medication.
To be sure this medication is helping your condition, your blood and urine will need to be tested often. This will help your doctor determine how long to treat you with EDTA.
Additional Endrate Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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