Enlon (Edrophonium Injection) Drug Information: Side Effects and Drug Interactions

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May 27, 2012

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Enlon

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

SIDE EFFECTS

Careful observation should be made for severe cholinergic reactions in the hyperreactive individual. The myasthenic patient in crisis who is being tested with Enlon (edrophonium injection) ^® should be observed for bradycardia or cardiac standstill and cholinergic reactions if an overdose is given.

The following reactions common to anticholinesterase agents may occur, although not all of these reactions have been reported with the administration of Enlon (edrophonium injection) ^®, probably because of its short duration of action and limited indications:

Eye:		Increased lacrimation, pupillary constriction, spasm of accommodation, diplopia, conjunctival hyperemia.
CNS:		Convulsions, dysarthria, dysphonia, dysphagia.
Respiratory:		Increased tracheobronchial secretions, laryngospasm, bronchiolar constriction, paralysis of muscles of respiration, central respiratory paralysis.
Cardiac:		Arrhythmias (especially bradycardia), fall in cardiac output leading to hypotension. Increased salivary, gastric and intestinal secretion, nausea, vomiting, increased peristalsis, diarrhea, abdominal cramps.
Skeletal Muscle:		Weakness, fasciculations.
Miscellaneous:		Increased urinary frequency and incontinence, diaphoresis.

DRUG INTERACTIONS

Care should be given when administering this drug to patients with symptoms of myasthenic weakness who are also on anticholinesterase drugs. Since symptoms of anticholinesterase overdose (cholinergic crisis) may mimic underdosage (myasthenic weakness), their condition may be worsened by the use of this drug. (See OVERDOSAGE section for treatment.)

Last reviewed on RxList: 1/15/2005
This monograph has been modified to include the generic and brand name in many instances.