Eovist (Gadoxetate Disodium Injection) Drug Information: Medication Guide and Patient Information

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May 27, 2012

Eovist

Liver Disease »

What is liver disease?

Liver disease is any disturbance of liver function that causes illness. The liver is responsible for many critical functions within the body and should it become diseased or injured, the loss of those functions can cause significant damage to the body. Liver disease is also referred to as hepatic disease.

Liver disease is a broad term that covers all the potential problems that may occur to cause the liver to fail to perform its designated functions. Usually, more than 75% or three quarters of liver tissue needs to be affected before decrease in function occurs.

The liver the largest solid organ in the body; and is also considered a gland because among its many functions, it makes and secretes bile. The liver is located in the upper right portion of the abdomen protected by the rib cage. It has two main lobes that are made up of tiny lobules. The liver cells have two different sources of blood supply. The hepatic ...

Read the Liver Disease article »

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Eovist

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PATIENT INFORMATION

Instruct patients receiving EOVIST to inform their physician or healthcare provider of the following:

if they are pregnant or breast feeding
if they have a previous history of allergic reaction to contrast media, a history of bronchial asthma or allergic respiratory disorder, or recent administration of a gadolinium based contrast agent
if they have any history of kidney and/or liver disease
of all medications they may be taking, including those taken without prescription

GBCAs increase the risk of NSF among patients with impaired elimination of drugs. To counsel patients at risk of NSF:

Describe the clinical manifestation of NSF
Describe procedures to screen for the detection of renal impairment

Instruct the patients to contact their physician if they develop signs or symptoms of NSF following EOVIST administration, such as burning, itching, swelling, scaling, hardening and tightening of the skin; red or dark patches on the skin; stiffness in joints with trouble moving, bending or straightening the arms, hands, legs or feet; pain in the hip bones or ribs; or muscle weakness. Inform patients that they may experience:

reactions along the venous injection site, such as mild and transient burning or pain or feeling of warmth or coldness at the injection site
side effects of feeling hot, nausea, and headache

Last reviewed on RxList: 12/7/2011
This monograph has been modified to include the generic and brand name in many instances.