Erygel

Erygel®
(erythromycin topical) Gel USP 2%

For Dermatologic Use Only-Not for Ophthalmic Use

Erygel

DRUG DESCRIPTION

ERYGEL® (erythromycin topical gel) Topical Gel contains erythromycin (3R*, 4S*, 5S*,6R*,7R*, 9R*, 11R*, 12R*, 13S*, 14R*)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12, 13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-ß-D-xylo-hexopyranosyl] oxy] oxacy-clotetradecane-2,10-dione), for topical dermatological use. Erythromycin is a macrolide antibiotic produced from a strain of Saccaropolyspora erythraea (formerly Streptomyces erythreus). It is a base and readily forms salts with acids.

Chemically, erythromycin is C37H67NO13. It has the following structural formula:

STRUCTURAL FORMULA

Erygel (erythromycin) structural formula illustration

Erythromycin has a molecular weight of 733.94. It is a white or slightly yellow, odorless or practically odorless, bitter crystalline powder. Erythromycin is very soluble in very polar organic solvents such as alcohols, acetone, chloroform, acetonitrile and ethyl acetate. It is moderately soluble in less polar solvents such as ether, dichloroethyl-ene and amyl acetate. It is slightly soluble in nonpolar solvents such as hexane. It is very poorly soluble in water.

Each gram of ERYGEL® (erythromycin topical gel) Topical Gel contains 20 mg of erythromycin, USP in a base of alcohol 92% and hydroxypropyl cellulose.

What are the possible side effects of erythromycin topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using erythromycin topical and call your doctor at once if you have any of these serious side effects:

  • severe burning, stinging, or redness;
  • oozing or other signs of skin infection;
  • worsening of your skin condition; or
  • diarrhea that is watery or bloody.

Less serious side effects may include:

  • mild skin irritation or tenderness;
  • dry or oily...

Read All Potential Side Effects and See Pictures of Erygel »

What are the precautions when taking erythromycin topical gel (Erygel)?

Before using erythromycin, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (e.g., azithromycin, clarithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before...

Read All Potential Precautions of Erygel »

Last reviewed on RxList: 9/10/2008
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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