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Erythromycin Ethylsuccinate

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E.E.S.

E.E.S. 200 Liquid
(erythromycin ethylsuccinate for oral suspension) Suspension

E.E.S. 400 Liquid
(erythromycin ethylsuccinate for oral suspension) Suspension

E.E.S. Granules
(erythromycin ethylsuccinate for oral suspension) Granule, For Suspension

E.E.S. 400 Filmtab Tablets
(erythromycin ethylsuccinate tablets) Tablet, Film Coated

To reduce the development of drug-resistant bacteria and maintain the effectiveness (erythromycin ethylsuccinate) of E.E.S. (erythromycin ethylsuccinate) and other antibacterial drugs, E.E.S. (erythromycin ethylsuccinate) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

DRUG DESCRIPTION

Erythromycin is produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics. It is basic and readily forms salts with acids. The base, the stearate salt, and the esters are poorly soluble in water. Erythromycin ethylsuccinate is an ester of erythromycin suitable for oral administration. Erythromycin ethylsuccinate is known chemically as erythromycin 2'-(ethylsuccinate). The molecular formula is C43H75NO16 and the molecular weight is 862.06. The structural formula is:

Erythromycin Structural Formula Illustration

E.E.S. (erythromycin ethylsuccinate) Granules are intended for reconstitution with water. Each 5-mL teaspoonful of reconstituted cherry-flavored suspension contains erythromycin ethylsuccinate equivalent to 200 mg of erythromycin.

The pleasant tasting, fruit-flavored liquids are supplied ready for oral administration.

E.E.S. 200 Liquid (erythromycin ethylsuccinate) : Each 5-mL teaspoonful of fruit-flavored suspension contains erythromycin ethylsuccinate equivalent to 200 mg of erythromycin.

E.E.S. (erythromycin ethylsuccinate) 400 Liquid: Each 5-mL teaspoonful of orange-flavored suspension contains erythromycin ethylsuccinate equivalent to 400 mg of erythromycin.

Granules and ready-made suspensions are intended primarily for pediatric use but can also be used in adults.

E.E.S. (erythromycin ethylsuccinate) 400® Filmtab® Tablets: Each tablet contains erythromycin ethylsuccinate equivalent to 400 mg of erythromycin.

The Filmtab® tablets are intended primarily for adults or older children.

Inactive Ingredients

E.E.S. 200 Liquid (erythromycin ethylsuccinate) : FD&C Red No. 40, methylparaben, polysorbate 60, propylparaben, sodium citrate, sucrose, water, xanthan gum and natural and artificial flavors.

E.E.S. (erythromycin ethylsuccinate) 400 Liquid: D&C Yellow No. 10, FD&C Yellow No. 6, methylparaben, polysorbate 60, propylparaben, sodium citrate, sucrose, water, xanthan gum and natural and artificial flavors.

E.E.S. (erythromycin ethylsuccinate) Granules: Citric acid, FD&C Red No. 3, magnesium aluminum silicate, sodium carboxymethylcellulose, sodium citrate, sucrose and artificial flavor.

E.E.S. (erythromycin ethylsuccinate) 400 Filmtab Tablets: Cellulosic polymers, confectioner's sugar (contains corn starch), corn starch, D&C Red No. 30, D&C Yellow No. 10, FD&C Red No. 40, magnesium stearate, polacrilin potassium, polyethylene glycol, propylene glycol, sodium citrate, sorbic acid, and titanium dioxide.

What are the possible side effects of erythromycin?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • severe dizziness, fainting, fast or pounding heartbeats;
  • diarrhea that is watery or bloody;
  • hearing problems;
  • vomiting or fussiness after eating (in a child taking erythromycin);
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);...

Read All Potential Side Effects and See Pictures of E.E.S. »

What are the precautions when taking erythromycin ethylsuccinate (E.E.S.)?

Before taking erythromycin, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics (such as azithromycin, clarithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, a certain type of muscle disease (myasthenia gravis).

Erythromycin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention...

Read All Potential Precautions of E.E.S. »

Last reviewed on RxList: 2/11/2009
This monograph has been modified to include the generic and brand name in many instances.

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