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In this Article

• What is esterified estrogens and methyltestosterone (Estratest)?
• What are the possible side effects of esterified estrogens and methyltestosterone?
• What is the most important information I should know about esterified estrogens and methyltestosterone?
• What should I discuss with my health care provider before using esterified estrogens and methyltestosterone?
• How should I use esterified estrogens and methyltestosterone?
• What happens if I miss a dose?
• What happens if I overdose?
• What should I avoid while using esterified estrogens and methyltestosterone?
• What other drugs will affect esterified estrogens and methyltestosterone?
• Where can I get more information?

What should I discuss with my health care provider before using esterified estrogens and methyltestosterone?

Esterified estrogens and methyltestosterone should not be used to prevent heart disease or stroke.

Do not use esterified estrogens and methyltestosterone if you have:

• liver disease;
• a recent history of heart attack, stroke or circulation problems;
• abnormal vaginal bleeding that a doctor has not checked;
• any type of breast, uterine, or hormone-dependent cancer; or
• if you are pregnant or breast-feeding.

Before taking this medication, tell your doctor if you have:

• high blood pressure, heart disease, or coronary artery disease;
• high cholesterol or triglycerides;
• kidney disease;
• asthma;
• epilepsy or other seizure disorder;
• migraines;
• endometriosis;
• diabetes;
• lupus;
• depression;
• gallbladder disease;
• if you smoke; or
• if you have had your uterus removed (hysterectomy).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

Esterified estrogens and methyltestosterone increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using esterified estrogens and methyltestosterone may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using esterified estrogens and methyltestosterone.

Long-term esterified estrogens and methyltestosterone treatment may increase your risk of stroke. Talk with your doctor about your individual risks before using esterified estrogens and methyltestosterone long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

FDA pregnancy category X. This medication can cause birth defects. Do not use esterified estrogens and methyltestosterone if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Esterified estrogens and methyltestosterone can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby.

How should I use esterified estrogens and methyltestosterone?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label.

This medication is usually taken in a cycle of 3 weeks on and 1 week off. Follow your doctor's instructions.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using esterified estrogens and methyltestosterone.

If you need to have any type of medical tests or surgery, or if you will be on bed rest, you may need to stop using this medication for a short time. Esterified estrogens and methyltestosterone may also cause unusual results with certain medical tests. Tell any doctor who treats you that you are taking this medication.

Store this medication at room temperature away from moisture and heat.