Slideshows Images Quizzes

Estratest

Last reviewed on RxList: 7/18/2008
Estratest Side Effects Center

Last reviewed on RxList 01/06/2017

Estratest (esterified estrogens and methyltestosterone) is a combination of female sex hormones and a form of the male hormone testosterone used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation.. Common side effects of Estratest include:

  • dizziness,
  • lightheadedness,
  • headache,
  • stomach upset,
  • bloating,
  • nausea,
  • weight changes,
  • increased/decreased interest in sex,
  • breast tenderness/swelling/pain,
  • hair loss,
  • depression,
  • anxiety,
  • impotence, or
  • difficulty having an orgasm.

Tell your doctor if you have unlikely but serious side effects of Estratest including:

  • mental/mood changes (e.g., severe depression, memory loss),
  • breast lumps,
  • swelling of hands or feet,
  • unusual vaginal bleeding (e.g., spotting, breakthrough bleeding, prolonged or recurrent bleeding),
  • unusual vaginal discharge/itching/odor,
  • changes in skin color,
  • yellowing eyes or skin,
  • unusual tiredness,
  • stomach or abdominal pain,
  • persistent nausea or vomiting,
  • dark urine, or
  • worsening of seizures.

The usual dosage range is 1 to 2 tablets of Estratest taken before bed once daily as recommended by the physician. Use the lowest dose that will control symptoms and discontinue as soon as possible. Administration should be cyclic (e.g., three weeks on and one week off). Estratest may interact with blood thinners, insulin, ketoconazole, St. John's wort, rifampin, antidepressants, seizure medicines, antibiotics, or HIV/AIDS medicines. Tell your doctor all medications and supplements you are taking. Estratest must not be used during pregnancy. It may harm a fetus. This medication is not usually used in women of childbearing age and is unlikely to be used during pregnancy or breastfeeding.

Our Estratest (esterified estrogens and methyltestosterone) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Estratest Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, problems with vision, speech, or balance;
  • swelling, rapid weight gain;
  • confusion, unusual thoughts or behavior;
  • pain, swelling, or tenderness in your stomach;
  • nausea, stomach pain, loss of appetite jaundice (yellowing of the skin or eyes);
  • breast lump, nipple discharge;
  • acne, skin color changes, increased facial hair, male pattern baldness, voice changes; or
  • changes in your menstrual periods, break-through bleeding.

Less serious side effects may include:

  • mild nausea, stomach upset;
  • swollen or painful breasts;
  • headache;
  • hair loss;
  • depression, anxiety; or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Estratest (Esterified Estrogens and Methyltestosterone)

Estratest Professional Information

SIDE EFFECTS

See BOXED WARNINGS, WARNINGS and PRECAUTIONS.

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The adverse reaction information from clinical trials does, however, provide a basis for identifying the adverse events that appear to be related to drug use and for approximating rates.

Associated with Estrogens

(See WARNINGS regarding induction of neoplasia, adverse effects on the fetus, increased incidence of gallbladder disease, and adverse effects similar to those of oral contraceptives, including thromboembolism). The following additional adverse reactions have been reported with estrogen and/or progestin therapy.

Genitourinary System: Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding; spotting; dysmenorrhea, increase in size of uterine leiomyomata; vaginitis, including vaginal candidiasis; change in amount of cervical secretion; changes in cervical ectropion; ovarian cancer; endometrial hyperplasia; endometrial cancer; cystitis-like syndrome.

Breasts: Tenderness; enlargement; pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer.

Cardiovascular: Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure.

Gastrointestinal: Nausea; vomiting; abdominal cramps; bloating; cholestatic jaundice; increased incidence of gallbladder disease; pancreatitis, enlargement of hepatic hemangiomas.

Skin: Chloasma or melasma that may persist when drug is discontinued; erythema multiforme; erythema nodosum; hemorrhagic eruption; loss of scalp hair; hirsutism; pruritus, rash.

Eyes: Retinal vascular thrombosis, steepening of corneal curvature, intolerance to contact lenses.

Central Nervous System: Headache, migraine, dizziness; mental depression; chorea; nervousness; mood disturbances; irritability; exacerbation of epilepsy, dementia.

Miscellaneous: Increase or decrease in weight; reduced carbohydrate tolerance; aggravation of porphyria; edema; arthralgias; leg cramps; changes in libido; urticaria, angioedema, anaphylactoid/anaphylactic reactions; hypocalcemia; exacerbation of asthma; increased triglycerides.

Associated with Methyltestosterone

Endocrine and Urogenital

Female: The most common side effects of androgen therapy are amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement. The latter usually is not reversible after androgens are discontinued. When administered to a pregnant woman, androgens cause virilization of external genitalia of the female fetus.

Skin and Appendages: Hirsutism, male pattern of baldness, and acne.

Fluid and Electrolyte Disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.

Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function test, rarely hepatocellular neoplasms, and peliosis hepatis. (See WARNINGS.)

Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.

Central Nervous System: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.

Metabolic: Increased serum cholesterol.

Miscellaneous: Inflammation and pain at the site of intramuscular injection or subcutaneous implantation of testosterone containing pellets, stomatitis with buccal preparations, and rarely anaphylactoid reactions.

Read the entire FDA prescribing information for Estratest (Esterified Estrogens and Methyltestosterone)

Related Resources for Estratest

Read the Estratest User Reviews »

© Estratest Patient Information is supplied by Cerner Multum, Inc. and Estratest Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors