Recommended Topic Related To:

Ethiodol

"A unique type of poster placed in exam rooms helped reduce unnecessary antibiotic prescriptions for respiratory infections during flu season. The approach could help reduce costs and extend the usefulness of these drugs.

Antibiotics a"...

Ethiodol

Warnings
Precautions

WARNINGS

In Hysterosalpingography

Ethiodol (ethiodized oil) is not intended for use in bronchography and, therefore, is not to be introduced into the bronchial tree. A history of sensitivity to iodine or to other contrast materials is not an absolute contraindication to Ethiodol (ethiodized oil) , but calls for extreme caution. All procedures utilizing contrast media carry a definite risk of adverse reactions. While most reactions are minor, life threatening and fatal reactions may occur without warning. The risk/benefit factor should always be carefully evaluated. At all times a fully equipped emergency cart and resuscitation equipment should be readily available, and personnel competent in recognizing and treating reactions of all severity should be on hand.

In Lymphography

The use of intralymphatic Ethiodol (ethiodized oil) presents a significant hazard in patients with pre-existing pulmonary disease characterized by a decrease in pulmonary diffusing capacity and/or pulmonary blood flow. A few fatalities have been noted in such patients. With reference to this potential complication, recent studies indicate a significant decrease in both pulmonary diffusing capacity and pulmonary capillary blood flow following Ethiodol (ethiodized oil) lymphography without appreciable concomitant clinical manifestations. Also, care should be exercised in patients with other types of pulmonary disease in view of the more frequent incidence of overt pulmonary complications such as pulmonary infarction, in these groups. However, it is to be noted that pulmonary infarction, although rare, has occurred in patients without evidence of pre-existing pulmonary disease.

The safety of intralymphatic Ethiodol (ethiodized oil) has not been established in pregnant women, and accordingly, its use should be restricted to such situations where it is deemed necessary.

PRECAUTIONS

In Hysterosalpingography

General

Since iodine-containing contrast materials may alter the results of certain thyroid function tests, such tests, if indicated, should be performed prior to the administration of this drug. Pulmonary embolization of the contrast material may occur if hysterosalpingography is performed under conditions which may lead to intravasation of the contrast materials. These conditions include uterine bleeding, recent curettage or conization and injection of the contrast material under excessive pressure.

Carcinogenesis, Mutagenesis, and Impairment of Fertility

Long-term studies in animals have not been performed to evaluate carcinogenic potential, mutagenesis, or whether Ethiodol (ethiodized oil) can affect fertility in males or females.

Pregnancy Category C

Animal reproduction studies have not been conducted with Ethiodol (ethiodized oil) . It is also not known whether Ethiodol (ethiodized oil) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Ethiodol (ethiodized oil) should be administered to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Ethiodol (ethiodized oil) , a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

In Lymphography

General

Although subclinical pulmonary embolization occurs in a majority of patients following Ethiodol (ethiodized oil) lymphography, clinical evidence of such embolization is infrequent and is usually of a transient nature. Such clinical manifestations are usually immediate, but may be delayed from a few hours to days. It would appear that it is advantageous to use the smallest volume of Ethiodol (ethiodized oil) necessary for radiographic visualization. For this reason, and to prevent inadvertent venous administration, radiographic monitoring of patients is recommended during the injection of Ethiodol (ethiodized oil) .

The timing and choice of anesthesia following Ethiodol (ethiodized oil) injection may be influenced by consideration of the above noted decrease in pulmonary and capillary blood flow and diffusing capacity. It should be noted that although an average of 2 to 3 days was required for complete reversibility for such tests, an occasional patient required up to 12 days to return to baseline values.

PBI determination of thyroid uptake studies should be carried out prior to the lymphographic procedure because interference with these tests may be anticipated for as long as one year. In the presence of known iodine sensitivity, Ethiodol (ethiodized oil) lymphography should be carried out with greatest precaution.

Carcinogenesis, Mutagenesis, and Impairment of Fertility

Long-term studies in animals have not been performed to evaluate carcinogenic potential, mutagenesis, or whether Ethiodol (ethiodized oil) can affect fertility in males or females.

Pregnancy Category C

Animal reproduction studies have not been conducted with Ethiodol (ethiodized oil) . It is also not known whether Ethiodol (ethiodized oil) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Ethiodol (ethiodized oil) should be administered to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Ethiodol (ethiodized oil) , a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Last reviewed on RxList: 6/3/2009
This monograph has been modified to include the generic and brand name in many instances.

Warnings
Precautions
A A A

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.