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(enflurane, USP) Liquid For Inhalation


ETHRANE (enflurane, USP), a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug. It is 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether (CHF2OCF2CHFCl). The boiling point is 56.5C at 760 mm Hg, and the vapor pressure (in mm Hg) is 175 at 20C, 218 at 25C, and 345 at 36C. Vapor pressures can be calculated using the equation:

log10Pvap = A + B/T A = 7.967
B = -1678.4
T = C + 273.16 (Kelvin)

The specific gravity (25/25C) is 1.517. The refractive index at 20C is 1.3026-1.3030. The blood/gas coefficient is 1.91 at 37C and the oil/gas coefficient is 98.5 at 37C.

Enflurane is a clear, colorless, stable liquid whose purity exceeds 99.9% (area percent by gas chromatography). No stabilizers are added as these have been found, through controlled laboratory tests, to be unnecessary even in the presence of ultraviolet light. Enflurane is stable to strong base, does not decompose in contact with soda lime (at normal operating temperatures), and does not react with aluminum, tin, brass, iron or copper. The partition coefficients of enflurane at 25C are 74 in conductive rubber and 120 in polyvinyl chloride.

Last reviewed on RxList: 12/5/2016
This monograph has been modified to include the generic and brand name in many instances.

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