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Ethyol

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Ethyol

ETHYOL®
(amifostine) for Injection

DRUG DESCRIPTION

ETHYOL (amifostine) is an organic thiophosphate cytoprotective agent known chemically as 2-[(3-aminopropyl)amino]ethanethiol dihydrogen phosphate (ester) and has the following structural formula:

H2N(CH2)3NH(CH2)2S-PO3H2

Amifostine is a white crystalline powder which is freely soluble in water. Its empirical formula is C5H15N2O3PS and it has a molecular weight of 214.22.

ETHYOL is the trihydrate form of amifostine and is supplied as a sterile lyophilized powder requiring reconstitution for intravenous infusion. Each single-use 10 mL vial contains 500 mg of amifostine on the anhydrous basis.

What are the possible side effects of amifostine (Ethyol)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching; chest tightness, difficult breathing; fever or chills; swelling of your face, lips, tongue, or throat.

Some of the side effects of amifostine may occur up to several weeks after you receive this medication.

Tell your caregiver right away if you have a serious side effect such as:

  • feeling like you might pass out;
  • chest pain, fast or slow heart rate;
  • weak or shallow breathing;
  • seizure (convulsions);
  • urinating less than usual or not at...

Read All Potential Side Effects and See Pictures of Ethyol »

What are the precautions when taking amifostine (Ethyol)?

Before receiving amifostine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: low/high blood pressure, heart disease (e.g., irregular heartbeat, congestive heart failure), kidney disease, previous stroke.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

During pregnancy, this medication should be used only when clearly needed. Discuss the...

Read All Potential Precautions of Ethyol »

Last reviewed on RxList: 8/18/2008
This monograph has been modified to include the generic and brand name in many instances.

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Ethyol - User Reviews

Ethyol User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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